187 results found
    1. Immunology and Inflammation

    Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

    Gabriela Krejčová, Adéla Danielová ... Adam Bajgar
    Activated Drosophila macrophages undergo transient metabolic remodeling towards Hypoxia inducible factor 1 α-driven aerobic glycolysis, a program that induces systemic metabolic changes and is crucial for resistance to infection.
    1. Developmental Biology

    Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

    Xinde Zheng, Leah Boyer ... Tony Hunter
    The shutoff of aerobic glycolysis in neuronal differentiation is essential for neuronal survival.
    1. Cancer Biology
    2. Cell Biology

    A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

    Kenneth Kin Lam Wong, Jenny Zhe Liao, Esther M Verheyen
    Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.
    1. Cell Biology
    2. Neuroscience

    Glycolytic reliance promotes anabolism in photoreceptors

    Yashodhan Chinchore, Tedi Begaj ... Constance L Cepko
    Aerobic glycolysis in rod photoreceptors of adult mice is regulated by allostery and FGF signaling and is required for maintaining outer segments.
    1. Biochemistry and Chemical Biology

    Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

    Alexander A Shestov, Xiaojing Liu ... Jason W Locasale
    A new computational model of the Warburg Effect reveals that the rate-limiting step of glycolysis is variable, identifies new control mechanisms, and could help to predict the responses to targeting glycolysis to treat cancer.
    1. Cell Biology
    2. Immunology and Inflammation

    Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

    Lindsey Araujo, Phillip Khim ... Michael Demetriou
    Metabolic switches between oxidative phosphorylation and aerobic glycolysis plus glutaminolysis direct T cell function by altering the flux of glucose and glutamine to N-glycosylation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

    Jelle van den Ameele, Andrea H Brand
    Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: Warburg’s vision

    James B Hurley
    Genetic tools help to dissect the relationship between aerobic glycolysis and anabolic metabolism in the retinas of mice.
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    1. Cell Biology
    2. Developmental Biology

    In vivo genetic dissection of tumor growth and the Warburg effect

    Cheng-Wei Wang, Arunima Purkayastha ... Utpal Banerjee
    A Drosophila tumor model reveals how the activation of an oncogenic pathway can lead to both tumor growth and a reprogramming of metabolism known as the Warberg effect.
    1. Neuroscience

    The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

    Carlos Manlio Díaz-García, Dylan J Meyer ... Gary Yellen
    When neurons are stimulated, calcium entry into mitochondria upregulates mitochondrial energy production, but glycolytic energy production in the cytosol is stimulated by elevated energy demand, not Ca2+ signaling.

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