This work validates PIP4K gamma as pharmacological target to ameliorate Huntington's disease.

Acetylcholine plays a multifold role in modulating neuronal mismatch in auditory cortex, affecting the precision of prediction error signaling and gating prediction errors to hierarchically higher processing levels.

Comprehensive dataset of high-level cognitive assessment in mouse models of neurodegeneration, accompanied by an open-access database/repository to change the paradigm of how cognitive studies in animal models can be shared/re-used.

Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.

High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.

Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.

The aldehyde 4-hydroxy-2-nonenal is a novel component of the host antimicrobial reactive oxygen burst, and the bacterium Listeria monocytogenes encodes genes specifically for its detoxification.

Genetic disruption of sodium-hydrogen exchanger 6 (NHE6) reduces amyloid plaques in humanized Alzheimer's disease mouse models and restores normal synaptic responses to neuromodulatory input in humanized ApoE4-expressing animals.