139 results found
    1. Neuroscience

    An excitatory amacrine cell detects object motion and provides feature-selective input to ganglion cells in the mouse retina

    Tahnbee Kim, Florentina Soto, Daniel Kerschensteiner
    The mouse visual system is able to detect small moving objects due to the activity of VG3-amacrine cells, an unusual type of modulatory cell that uses the transmitter glutamate to activate retinal output cells.
    Short Report Updated
    Formats available:
    • HTML
    • PDF
    1. Neuroscience

    Retinal direction selectivity in the absence of asymmetric starburst amacrine cell responses

    Laura Hanson, Santhosh Sethuramanujam ... Gautam B Awatramani
    Experimental and computational models reveal how parallel 'core' mechanisms shape direction selectivity at the dendrites of starburst amacrine cells and ganglion cells in the mouse retina.
    1. Neuroscience

    Local processing in neurites of VGluT3-expressing amacrine cells differentially organizes visual information

    Jen-Chun Hsiang, Keith P Johnson ... Daniel Kerschensteiner
    Neurite arbors of VGluT3-expressing amacrine cells (VG3-ACs) process visual information locally uniformly detecting object motion while varying in contrast preferences; and in spite of extensive overlap between arbors of neighboring cells population activity in the VG3-AC plexus encodes stimulus positions with subcellular precision.
    Short Report Updated
    Formats available:
    • HTML
    • PDF
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray, Suva Roy ... Jeremy N Kay
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Neuroscience

    Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells

    John A Gaynes, Samuel A Budoff ... Alon Poleg-Polsky
    A combination of glutamate imaging, multicompartmental modeling, and machine learning elucidates the peak theoretical and actual contributions of heterogeneous kinetics of presynaptic inputs to the computation of directional selectivity in retinal starburst amacrine cells.
    1. Neuroscience

    A cell atlas of the chick retina based on single-cell transcriptomics

    Masahito Yamagata, Wenjun Yan, Joshua R Sanes
    A molecular atlas of the chick retina provides a comprehensive classification and characterization of 136 cell types, yielding novel insights into retinal structure, function, development, and evolution.
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon, Catherine Theriault ... Arjun Krishnaswamy
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Neuroscience

    Spatiotemporal properties of glutamate input support direction selectivity in the dendrites of retinal starburst amacrine cells

    Prerna Srivastava, Geoff de Rosenroll ... Gautam Bhagwan Awatramani
    Two-photon glutamate imaging reveals that 'sustained' and 'transient' input are systematically arranged along single starburst dendrites, supporting the 'space-time' wiring model for direction selectivity.
    1. Neuroscience

    Light-dependent pathways for dopaminergic amacrine cell development and function

    Teona Munteanu, Katelyn J Noronha ... Tiffany M Schmidt
    Rods, not ipRGCs, are the major retinal photoreceptor impacting development of dopaminergic signaling in the retina.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim, Soyeon Lim ... Jin Woo Kim
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.

Refine your results by:

Type
Research categories