Tahnbee Kim, Florentina Soto, Daniel Kerschensteiner
The mouse visual system is able to detect small moving objects due to the activity of VG3-amacrine cells, an unusual type of modulatory cell that uses the transmitter glutamate to activate retinal output cells.
Laura Hanson, Santhosh Sethuramanujam ... Gautam B Awatramani
Experimental and computational models reveal how parallel 'core' mechanisms shape direction selectivity at the dendrites of starburst amacrine cells and ganglion cells in the mouse retina.
Jen-Chun Hsiang, Keith P Johnson ... Daniel Kerschensteiner
Neurite arbors of VGluT3-expressing amacrine cells (VG3-ACs) process visual information locally uniformly detecting object motion while varying in contrast preferences; and in spite of extensive overlap between arbors of neighboring cells population activity in the VG3-AC plexus encodes stimulus positions with subcellular precision.
Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
John A Gaynes, Samuel A Budoff ... Alon Poleg-Polsky
A combination of glutamate imaging, multicompartmental modeling, and machine learning elucidates the peak theoretical and actual contributions of heterogeneous kinetics of presynaptic inputs to the computation of directional selectivity in retinal starburst amacrine cells.
A molecular atlas of the chick retina provides a comprehensive classification and characterization of 136 cell types, yielding novel insights into retinal structure, function, development, and evolution.
A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
Prerna Srivastava, Geoff de Rosenroll ... Gautam Bhagwan Awatramani
Two-photon glutamate imaging reveals that 'sustained' and 'transient' input are systematically arranged along single starburst dendrites, supporting the 'space-time' wiring model for direction selectivity.