1,170 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

    Katia Ancelin, Laurène Syx ... Edith Heard
    The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.
    1. Cell Biology
    2. Developmental Biology

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat, Mette Handberg-Thorsager ... Guillaume Balavoine
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.
    1. Neuroscience

    In vivo assessment of the neural substrate linked with vocal imitation accuracy

    Julie Hamaide, Kristina Lukacova ... Annemie Van der Linden
    Song learning accuracy can be predicted and traced in the structural properties of the brains of juvenile male zebra finches already at 20 days post-hatching.
    1. Neuroscience

    Uncovering a ‘sensitive window’ of multisensory and motor neuroplasticity in the cerebrum and cerebellum of male and female starlings

    Jasmien Orije, Emilie Cardon ... Annemie Van der Linden
    Despite the structural sexual dimorphism in the song control system, both male and female starlings experience similar seasonal neuroplasticity in multisensory systems and cerebellum during the photosensitive phase, which acts as a sensitive window of plasticity.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

    Anneli Cooper, Hamidou Ilboudo ... Annette MacLeod
    Common kidney disease risk variants in African populations are associated with reduced susceptibility to deadly African trypanosomes.
    1. Cell Biology
    2. Neuroscience

    Desmosomal connectomics of all somatic muscles in an annelid larva

    Sanja Jasek, Csaba Verasztó ... Gáspár Jékely
    Volume-EM reconstruction of a whole-body desmosomal connectome including all muscles and their desmosomal partners in a Platynereis larva provides a detailed view of the organisation of the entire locomotor system in an animal.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

    Vivian Vasconcelos Costa, Michelle A Sugimoto ... Mauro Martins Teixeira
    An inadequate engagement of the inflammation resolution circuit centred on Annexin A1 contributes to the excessive inflammation observed in severe DENV infection, suggesting FPR2/ALX agonists as a therapeutic target for dengue disease.
    1. Cell Biology

    Apical annuli are specialised sites of post-invasion secretion of dense granules in Toxoplasma

    Sara Chelaghma, Huiling Ke ... Ross F Waller
    Apicomplexan parasites secrete proteins to manipulate their hosts from sub-apical openings in their cell pellicle that are distinct from the apical complex from where invasion factors are secreted.
    1. Cell Biology

    Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair

    Justin Krish Williams, Jordan Matthew Ngo ... Randy Schekman
    Plasma membrane damage causes the release of exosomes from cultured human cells.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Discovery of methylfarnesoate as the annelid brain hormone reveals an ancient role of sesquiterpenoids in reproduction

    Sven Schenk, Christian Krauditsch ... Florian Raible
    A small brain-derived lipid prevents bristle worms from entering maturation and death, challenging current views of hormone evolution and pesticide specificity.

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