The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.

Lung interstitial macrophages are strategically positioned underneath the bronchial airway epithelium and enriched at airway bifurcations for immunosurveillance of the conducting airway lumen and the initiation of adaptive immune responses.

Lymph node gp120 specific B cells extract locally injected HIV-1 gp120 from SIGN-R1 positive macrophages that line the subcapsular sinus overlying the lymph node interfollicular channels.

Novel antigen-targeting probes, featuring a cysteine-rich tag emitting fluorescence, offer unprecedented insight into antigen-specific immune responses.

A fully synthetic library of humanized single domain antibodies yields in vitro high affinity antibodies usable in cell biology and translational projects.

Intravital imaging with HIV-1 viral-like particle in mouse model reveals a mechanism for HIV-1 uptake by subcapsular sinus macrophages that facilitates HIV-1 spreading tofollicular dendritic and B cells.

A new, high-throughput in vivo MHC-I peptide minigene library platform shows that the naive immune system cannot eliminate cells presenting immunogenic antigens found at low frequencies within a growing tumor.

The absolute affinities of thousands of variant antibodies are measured in parallel using a combination of cell sorting and high-throughput DNA sequencing.

TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.

Antigen-phosphorothioate DNA conjugation provides a vaccination strategy where stable barcodes facilitate the detection and quantification of antigen using single-cell RNA sequencing.