416 results found
    1. Developmental Biology
    2. Plant Biology

    Three ancient hormonal cues co-ordinate shoot branching in a moss

    Yoan Coudert, Wojtek Palubicki ... C Jill Harrison
    The mosses and angiosperms have independently evolved mechanisms that use the same hormones-auxin, cytokinin and strigolactone-to regulate lateral shoot branching.
    1. Developmental Biology

    The invariant cleavage pattern displayed by ascidian embryos depends on spindle positioning along the cell's longest axis in the apical plane and relies on asynchronous cell divisions

    Rémi Dumollard, Nicolas Minc ... Alex McDougall
    Cell cycle asynchrony regulates apical cell shape to drive cell division orientation in the apical plane.
    1. Developmental Biology

    Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility

    Hervé Alégot, Pierre Pouchin ... Vincent Mirouse
    A morphogen gradient can trigger tissue elongation via a control of apical cell pulsing and without a planar cell polarity requirement.
    1. Cell Biology

    Robustness of the microtubule network self-organization in epithelia

    Aleksandra Z Płochocka, Miguel Ramirez Moreno ... Lyubov Chumakova
    Computational, theoretical, and in vivo studies reveal that in epithelia the self-organization of apical microtubules is robustly determined by cell geometry and minus-end distribution, not organism environment or genetics.
    1. Developmental Biology
    2. Physics of Living Systems

    Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination

    Hanqing Guo, Michael Swan, Bing He
    Combined optogenetic and computer modeling approaches reveal how mechanical bistability of the mesoderm epithelium works jointly with apical constriction to facilitate mesoderm invagination in Drosophila, a well-characterized model for epithelial folding.
    1. Neuroscience

    Context-dependent signaling of coincident auditory and visual events in primary visual cortex

    Thomas Deneux, Evan R Harrell ... Brice Bathellier
    Abrupt sounds boost coincident visual cortex responses which could help localization of sudden audio-visual events.
    1. Cell Biology
    2. Physics of Living Systems

    A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

    Xarxa Quiroga, Nikhil Walani ... Pere Roca-Cusachs
    Cell stretch release generates plasma membrane (PM) evaginations of ≈100 nm, triggering a local event of actin polymerization that flattens and recovers PM shape.
    1. Structural Biology and Molecular Biophysics

    Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE

    Yao Li, Yu Zhang ... Tingting Yang
    A multidisciplinary platform featured by patient-derived RPEs is established to study the disease-causing mechanisms of BEST1 mutations, and demonstrates gene-supplemented rescue of the mutation-caused deficiency in Ca2+-dependent Cl- current in human RPE.
    1. Developmental Biology

    Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways

    Ana Sofia Pinheiro, Vasilios Tsarouhas ... Christos Samakovlis
    During tracheal morphogenesis, the scavenger receptor Emp senses and responds to luminal cargo levels by initiating apical membrane endocytosis along the longitudinal tube axis to restrict airway elongation.
    1. Cancer Biology
    2. Developmental Biology

    Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells

    Deepti Prasad, Katharina Illek ... Anne-Kathrin Classen
    Deregulated cell fate specification pathways, including oncogenic Ras, cause activation of JNK-signaling at contact sites with wild type cells, which drives apoptosis and aberrant cell elimination in a contact-dependent manner.

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