2,374 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Apoptosis recognition receptors regulate skin tissue repair in mice

    Olivia Justynski, Kate Bridges ... Valerie Horsley
    After an injury to the skin, murine wounds upregulate apoptosis and efferocytosis pathways, which are required for effective healing and may similarly impact wound healing in diabetic patients.
    1. Stem Cells and Regenerative Medicine

    Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

    Lucy LeBlanc, Bum-Kyu Lee ... Jonghwan Kim
    During ES cell differentiation, Yap1 directly regulates apoptosis-related genes like Bcl-2 and Mcl-1 to attenuate apoptosis and promote cell survival to allow for successful cell fate changes.
    1. Cell Biology

    PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

    Shuxian Li, Lingbing Li ... Xietong Wang
    Airborne PM2.5 exposure triggers oxidative stress and mitochondrial apoptosis in placental trophoblast cells via the KLF9/CYP1A1 transcriptional axis, ultimately leading to adverse pregnancy outcomes.
    1. Cancer Biology
    2. Cell Biology

    A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis

    Jesusa Capera, Mireia Pérez-Verdaguer ... Antonio Felipe
    The association of caveolin with the potassium channel Kv1.3 fine-tunes cell survival and apoptosis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

    Christopher Duncan-Lewis, Ella Hartenian ... Britt A Glaunsinger
    Human cells respond to cytoplasmic mRNA depletion during early apoptosis by inhibiting RNA polymerase II transcription, thereby magnifying the gene expression shutdown during stress.
    1. Biochemistry and Chemical Biology

    Global cellular response to chemotherapy-induced apoptosis

    Arun P Wiita, Etay Ziv ... James A Wells
    The simultaneous monitoring of transcription, translational control, protein production and proteolysis in the same system can improve our understanding of how cancer cells respond to chemotherapy.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

    Justin M Jenson, Jeremy A Ryan ... Amy E Keating
    Short peptides that bind tightly to anti-apoptotic protein Bfl-1 but not other Bcl-2 family members provide a tool for diagnosing cancer cell survival mechanisms and a lead for developing new therapeutics.
    1. Cancer Biology

    A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

    Qiaomu Tian, Peng Zhang ... Anita S Chong
    CK21 emerges as a compelling candidate for pancreatic cancer treatment, and its capacity to target the NF-κB pathway, induce mitochondrial-mediated apoptosis, and do so with minimal toxicity is a significant stride in the quest for improved therapies.
    1. Developmental Biology

    Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

    Ainhoa Pérez-Garijo, Yaron Fuchs, Hermann Steller
    A common mechanism might regulate the communal death of cells in flies and mammals.
    1. Neuroscience

    Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence

    Sarah Rose Anderson, Jacqueline M Roberts ... Monica L Vetter
    In postnatal retina, neuronal apoptosis promotes a spectrum of microglial transcriptional states with varied dependence on CSF1R; TAM receptor Mer and complement receptor 3 mediate phagocytosis of dying neurons while altered CSF1R dependence requires Axl.

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