134 results found
    1. Cell Biology
    2. Plant Biology

    Developmental patterning function of GNOM ARF-GEF mediated from the cell periphery

    Maciek Adamowski, Ivana Matijević, Jiří Friml
    The plant developmental regulator GNOM performs its unique function from the cell periphery, through sequence features present in all its domains, and not by the control of endocytosis.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase

    Brian C Richardson, Steve L Halaby ... J Christopher Fromme
    A new structure reveals two Arf-GEF regulatory domains form a single structural unit that stimulates Arf-GEF activity.
    1. Cell Biology
    2. Plant Biology

    Delivery of endocytosed proteins to the cell–division plane requires change of pathway from recycling to secretion

    Sandra Richter, Marika Kientz ... Gerd Jürgens
    The same membrane trafficking cargo can change pathways mediated by different members of ARF-GEF family of vesicle formation regulators.
    1. Cell Biology

    Src activates retrograde membrane traffic through phosphorylation of GBF1

    Joanne Chia, Shyi-Chyi Wang ... Frederic A Bard
    Src phosphorylates GBF1, promoting binding of the Sec7 domain to Arf1 and the formation of GALNTs containing tubules emanating from the Golgi.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling

    Phi Luong, Matija Hedl ... Wayne I Lencer
    Inflammatory bowel disease risk-gene, INAVA and the ARF-GEF ARNO, regulates non-canonical cortical actin assembly and IL-1b signaling to maintain epithelial homeostasis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ARL3 activation requires the co-GEF BART and effector-mediated turnover

    Yasmin ElMaghloob, Begoña Sot ... Shehab Ismail
    BART is a co-GEF for ARL3 and maintains the active ARL3-GTP until it is recycled by ARL3 effectors.
    1. Cancer Biology

    MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

    Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
    Epigenetic regulator MLL3 is mutated and lost in human hepatocellular carcinoma due to its ability to activate a well-defined tumor suppressor and cell death in transformed cells.
    1. Cell Biology
    2. Plant Biology

    ER assembly of SNARE complexes mediating formation of partitioning membrane in Arabidopsis cytokinesis

    Matthias Karnahl, Misoon Park ... Gerd Jürgens
    SNARE proteins are delivered as complexes already from the endoplasmic reticulum along the secretory pathway to the cell division plane to mediate the formation of the partitioning membrane by vesicle fusion.
    1. Cell Biology

    Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

    Ryan S D'Souza, Jun Y Lim ... James E Casanova
    Calcium influx stimulates formation of ER/plasma membrane contacts adjacent to focal adhesions, and lipid transfer at these sites is required for adhesion disassembly during cell migration.

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