47 results found
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

    Paulina Fuentes, Fei Zhou ... Ralph Bock
    A combination of chloroplast transformation with nuclear transformation and large-scale metabolic screening of supertransformed plant lines has enabled an entire biochemical pathway to be transferred from a medicinal plant to a high-biomass crop.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

    Luana C Mathieu, Horace Cox ... Lise Musset
    The de novo selection of a mutation responsible for Plasmodium falciparum in vitro artemisinin resistance is confirmed in Guyana, making artemisinin combination therapies vulnerable to complete resistance in this region.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Genomic epidemiology of artemisinin resistant malaria

    MalariaGEN Plasmodium falciparum Community Project
    Plasmodium falciparum kelch13 mutations that cause artemisinin resistant malaria in Southeast Asia show markedly different patterns of evolutionary selection in Africa.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

    Barbara H Stokes, Satish K Dhingra ... David A Fidock
    Plasmodium falciparum K13 mutations confer resistance to the antimalarial artemisinin in Asian and African parasites, with most gene-edited mutant K13 African parasite lines showing a fitness cost that may predict slow dissemination of artemisinin resistance in high-transmission settings.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Artemisinin exposure at the ring or trophozoite stage impacts Plasmodium falciparum sexual conversion differently

    Harvie P Portugaliza, Shinya Miyazaki ... Alfred Cortés
    Treatment of malaria parasites with the frontline antimalarial drug artemisinin can increase the proportion of parasites that convert into transmission forms.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum

    Thiery Masserey, Tamsin Lee ... Melissa A Penny
    Models of malaria and treatment dynamics were combined with emulator-based global sensitivity analysis to elucidate the interplay between drug, biology, and epidemiological factors on the evolution of resistance to malaria treatments, including artemisinin.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Deconvoluting heme biosynthesis to target blood-stage malaria parasites

    Paul A Sigala, Jan R Crowley ... Daniel E Goldberg
    Insights into the basic metabolic architecture and adaptations of malaria parasites for growth within human erythrocytes exemplify how incisive knowledge of biochemical pathways and mechanisms may be leveraged to develop new therapies.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

    Kuan-Yi Lu, Charisse Flerida A Pasaje ... Emily Derbyshire
    Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.
  1. Annual report: 2016 in review

    A look back at eLife's achievements in 2016, notably in advocating for more open practises in sciences, building an open infrastructure for research communication and supporting early-career researchers.

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