444 results found
    1. Medicine

    RANK+TLR2+ myeloid subpopulation converts autoimmune to joint destruction in rheumatoid arthritis

    Weixin Zhang, Kathleen Noller ... Xu Cao
    The sialylation of RANK+TLR2+ monocytes contributes to osteoclastogenesis and bone destruction in rheumatoid arthritis.
    1. Immunology and Inflammation

    Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

    Jose U Scher, Andrew Sczesnak ... Dan R Littman
    The sequencing of microbial genomes reveals that the presence of a particular microbial species in the gut may increase the risk of the autoimmune disease rheumatoid arthritis.
    1. Immunology and Inflammation
    2. Medicine

    Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

    Dongjin Jeong, Hye Sung Kim ... Doo Hyun Chung
    Soluble Fas ligand interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor 5, exacerbating arthritis in a Fas-independent manner.
    1. Immunology and Inflammation

    BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages

    Jie Li, Liansheng Zhang ... Anning Lin
    Phosphorylation-mediated inactivation of pro-apoptotic BCL-2 family protein BAD confers the apoptosis resistance on synovial sublining macrophages, thereby contributing to the development of rheumatoid arthritis.
    1. Immunology and Inflammation

    Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

    Isobel C Mouat, Zachary J Morse ... Marc S Horwitz
    Latent gammaherpesvirus infection predisposes mice to develop more severe disease following induction of arthritis by elevating pathogenic interferon-gamma-expressing age-associated B cells.
    1. Immunology and Inflammation

    Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

    Gerdien Mijnheer, Nila Hendrika Servaas ... Femke van Wijk
    In localized autoimmune disease, there is autoantigen-driven expansion of both effector T cell and Treg clones that are highly persistent and are (re)circulating, and might represent interesting therapeutic targets.
    1. Medicine

    GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases

    Gaoran Ge, Qianping Guo ... Dechun Geng
    A new role is identified for GLI1 in modulating the inflammatory response of macrophages and the overaction of osteoclasts in collagen-induced arthritis by collaboratively regulating DNMT1 and DNMT3a.
    1. Immunology and Inflammation

    Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo

    Dana E Orange, Nathalie E Blachere ... Robert B Darnell
    By using immune cells called dendritic cells to deliver drugs, it is possible to target and kill specific members of another class of immune cell, known as T cells, and to prevent these cells from attacking the body's own tissues in cases of autoimmune disease.
    1. Immunology and Inflammation
    2. Medicine

    Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

    Niels JM Verstegen, Ruth R Hagen ... Carolien E van de Sandt
    SARS-CoV-2 experienced ocrelizumab-treated MS patients benefit from SARS-CoV-2 mRNA vaccination by inducing broadprotective CD8+ T-cells, whereas methotrexate-treated RA patients induce delayed but strong antibody responses, which support vaccine strategies for these patient groups.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Extensive transmission of microbes along the gastrointestinal tract

    Thomas SB Schmidt, Matthew R Hayward ... Peer Bork
    Microbial populations are continuous along the gastrointestinal tract, with increased transmission in colorectal cancer and rheumatoid arthritis patients.

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