Yan Gong, Julien Alassimone ... Dominique C Bergmann
Quantitative live-cell time-lapse imaging reveals that the spatial and temporal degree of cortical polarity domains reflects stem-cell division capacity in cells of the Arabidopsis plant leaf epidermis.
Asymmetric cell division is linked to cell-specific transcription by handoff of a key developmental regulator from the cytokinetic machinery to the adjacent cell pole where it oligomerizes to become stabilized and activated.
The Par complex controls spindle orientation during asymmetric cell division by phosphorylating the tumor suppressor Discs large, overcoming its autoinhibited state, and allowing it to bind the microtubule-binding protein GukHolder.
Receptors for two distinct pathways are linked to choreograph the dynamic interaction of Wnt on the stem cell membrane, which leads to the control of asymmetric cell division.
Felipe Mora-Bermúdez, Fumio Matsuzaki, Wieland B Huttner
Mammalian neural stem cells specifically regulate a subset of astral microtubules to govern the subtle changes in spindle orientation that underlie symmetric vs asymmetric cell division during embryonic cortical neurogenesis.
Jennifer J Banerjee, Birgit L Aerne ... Nicolas Tapon
Meru is a factor that provides tissue-specific information to the core polarity machinery by linking planar to apical-basal polarity in asymmetrically dividing sensory organ precursors.
Dan Zhang, Roxane P Spiegelhalder ... Michael T Raissig
The formation of stomatal 'helper cells' (=subsidiary cells) in grasses requires two opposing polarity domains with diverse roles in establishing division asymmetry.
A separation-of-function mutation reveals that a niche ligand receptor Dome functions in spindle orientation during asymmetric stem cell division by directly binding to Eb1, independent of its role in downstream JAK-STAT signaling.
Kanika Khanna, Javier Lopez-Garrido ... Elizabeth Villa
During sporulation, FtsAZ filaments mediating cell division in Bacillus subtilis are positioned asymmetrically around the septum only on the mother cell side, making the septum thinner than during vegetative growth.