42 results found
    1. Plant Biology

    Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal

    Heather M Meyer, José Teles ... Adrienne H K Roeder
    Fluctuations of a transcription factor that coincide with the G2 phase of the cell cycle pattern two interspersed cell fates in a multicellular system.
    1. Developmental Biology
    2. Plant Biology

    Cell type boundaries organize plant development

    Monica Pia Caggiano, Xiulian Yu ... Marcus G Heisler
    Leaf position, shape and orientation are pre-patterned by cell type boundaries in the shoot meristem.
    1. Cancer Biology

    Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

    Kotaro Shirakawa, Lan Wang ... Eric Verdin
    Salicylic acid, the precursor to aspirin, is an anti-tumor agent that blocks protein acetylation.
    1. Plant Biology

    Active suppression of a leaf meristem orchestrates determinate leaf growth

    John Paul Alvarez, Chihiro Furumizu ... John L Bowman
    A meristem acting at the margins of Arabidopsis leaves is suppressed by factors acting primarily in leaves and other determinate organs.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Mechanical force induces mitochondrial fission

    Sebastian Carsten Johannes Helle, Qian Feng ... Benoît Kornmann
    Mechanically stimulating mitochondria causes them to divide via the recruitment of the mitochondrial fission machinery to the mechanically strained site, showing that intracellular organelles can be mechanoresponsive.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters

    Chengcheng Fan, Douglas C Rees
    Multiple cryo-electron microscopy structures of a plant ABC transporter exporting glutathione derivatives captured a closed conformation proposed to enforce the export directionality, while a complex central to the coupling mechanism containing both glutathione and closed nucleotide binding domains remains elusive.
    1. Chromosomes and Gene Expression

    Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

    Merja Heinäniemi, Tapio Vuorenmaa ... Olli Lohi
    Convergent transcription and stalling of transcription are enriched at DNA breakpoints found in acute lymphoblastic leukemia and associate with DNA structures and sequences that mediate genetic instability.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

    Nuria Vilaplana-Lopera, Vincent Cuminetti ... Paloma Garcia
    Interplay between AML and stromal cells can initiate a mechanism involving gap junctions where ROS is transferred from cancer cells to stromal cells which then produce acetate which can in return be absorbed/utilised by the cancer cells.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Systematic bacterialization of yeast genes identifies a near-universally swappable pathway

    Aashiq H Kachroo, Jon M Laurent ... Edward M Marcotte
    Despite billions of years of divergence, a majority of prokaryotic genes can functionally replace their essential eukaryotic counterparts, revealing broad preservation of ancestral functions and identifying heme biosynthesis as a near-universally swappable pathway.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Proteome-wide signatures of function in highly diverged intrinsically disordered regions

    Taraneh Zarin, Bob Strome ... Alan M Moses
    Widespread, rapidly evolving disordered regions contain molecular features that are preserved over evolution and are associated with specific biological functions.

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