164 results found
    1. Microbiology and Infectious Disease

    Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery

    Arindam Mondal, Anthony R Dawson ... Andrew Mehle
    Host protein kinase C family members regulate influenza virus genome replication by phosphorylating the viral nucleoprotein and controlling assembly of the viral replication machinery.
    1. Neuroscience

    Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    The enzyme PKMzeta is crucial for the maintenance of long-term memories, but a closely related enzyme provides a back-up should PKMzeta fail, thus explaining the controversy over why deleting the gene for PKMzeta may not appear to impair memory.
    1. Neuroscience

    Memory: Forget me not

    Richard GM Morris
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    1. Neuroscience

    Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia

    Shanping Chen, Diancai Cai ... David L Glanzman
    Storage of long-term memory in Aplysia does not require stable synapses.
    1. Developmental Biology

    Type XVII collagen coordinates proliferation in the interfollicular epidermis

    Mika Watanabe, Ken Natsuga ... Hiroshi Shimizu
    Type XVII collagen, a transmembranous protein in basal keratinocytes, suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis.
    1. Computational and Systems Biology
    2. Neuroscience

    Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction

    Nadiatou T Miningou Zobon, Joanna Jędrzejewska-Szmek, Kim T Blackwell
    ERK activation during induction of long-term synaptic plasticity is enhanced by synergistic interactions among signaling pathways mediated by the synaptically located GTPase-activating protein, and each pathway contributes to different ERK temporal dynamics.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

    Rigney E Turnham, F Donelson Smith ... John D Scott
    Fibrolamellar carcinoma results from a genetic lesion that produces the DNAJ-PKAc fusion kinase, which is recruited into macromolecular complexes and is sensitive to combinations of signal transduction inhibitor drugs.
    1. Cell Biology
    2. Developmental Biology

    Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division

    Ognjen Golub, Brett Wee ... Kenneth E Prehoda
    The Par complex controls spindle orientation during asymmetric cell division by phosphorylating the tumor suppressor Discs large, overcoming its autoinhibited state, and allowing it to bind the microtubule-binding protein GukHolder.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Protein kinase C coordinates histone H3 phosphorylation and acetylation

    Zoulfia Darieva, Aaron Webber ... Andrew D Sharrocks
    Chromatin structure is altered following DNA replication stress through the activity of protein kinase C signalling which leads to functionally coupled histone H3 phosphorylation and acetylation events.
    1. Cell Biology
    2. Physics of Living Systems

    Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair

    Nicholas Mikolajewicz, Elizabeth A Zimmermann ... Svetlana V Komarova
    Bone cells exposed to physiological forces release ATP through repairable membrane injury, generating an intercellular signal that conveys the destructive potential of forces and the adaptive capacity of endangered cells.

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