Repulsive guidance cues enhance a dual-functioning axonal trafficking facilitator, allowing navigating axons to ensure proper pathfinding by coordinating positive extension and negative steering during nervous system development.

Shootin1a, through its spatially regulated phosphorylation within growth cones, mediates the gradient reading and mechanoresponse for netrin-1-induced axon guidance.

Lasso and latrophilin-1 interact across the synapse, while shed Lasso binds latrophilin-1 on distant growth cones and attracts them, providing a universal mechanism for short- and long-range axonal guidance.

Axon guidance genes are conserved regulators of neurodegeneration in Drosophila melanogaster and human inducible motor neuron models of UBQLN2-associated amyotrophic lateral sclerosis.

Alternative splicing of the Dcc gene, which is controlled by the NOVA RNA-binding proteins, is crucial during neuronal migration and axon guidance.

Dystroglycan interacts with multiple partners, including the transmembrane receptor Celsr3, to regulate axon tract formation throughout the developing nervous system.

Endoglycan fine-tunes the interaction between guidance molecules and surface receptors during axon guidance and cell migration.

Mathematical modelling explains why molecular gradients sometimes cause axons to only turn weakly.

The Netrin-1 and ephrin-B2 proteins act synergistically in the developing nervous system.

Axon guidance cues restrict sensory neuron synapse formation to a subset of equally acceptable interneuronal dendritic arbors during Drosophila locomotor circuit assembly.