91 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Blue light-induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence

    Udo Heintz, Ilme Schlichting
    Light absorption by the algal transcription factor Aureochrome 1a causes dimerization at the light-oxygen-voltage (LOV) sensing domain, which has implications for the design of synthetic photoreceptors for optogenetics.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function

    Ruben Rosas, Rhiannon R Aguilar ... Mair EA Churchill
    The lysine/glutamic acid/arginine region in chromatin assembly factor (CAF-1) forms a long single alpha-helix DNA-binding domain, facilitating the recognition of tetrasome-length DNA and linking functional domains within the CAF-1 architecture for efficient tetrasome assembly after DNA synthesis.
    1. Computational and Systems Biology

    The genetic landscape of a physical interaction

    Guillaume Diss, Ben Lehner
    First comprehensive analysis of how many different mutations combine within and between two genes to alter a molecular phenotype.
    1. Developmental Biology

    Roles of C/EBP class bZip proteins in the growth and cell competition of Rp (‘Minute’) mutants in Drosophila

    Jorge Blanco, Jacob C Cooper, Nicholas E Baker
    Xrp1 contributes to cell competition as a heterodimer with the Drosophila C/EBP homolog Irbp18 and although rapidly evolving is itself conserved beyond Drosophila.
    1. Cancer Biology
    2. Cell Biology

    MELK is not necessary for the proliferation of basal-like breast cancer cells

    Hai-Tsang Huang, Hyuk-Soo Seo ... Nathanael S Gray
    The inhibitory or deletion effect of MELK does not impair the proliferation of basal-like breast cancer cell lines.
    1. Developmental Biology

    Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1

    Antonio Galeone, Seung Yeop Han ... Hamed Jafar-Nejad
    N-glycanase 1 is required for a BMP autoregulatory loop in the visceral mesoderm and for intestinal development in Drosophila.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

    Ignacio Moraga, Jamie B Spangler ... K Christopher Garcia
    Synthetic cytokines engage new signaling programs with therapeutic potential.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

    Christian Arquint, Anna-Maria Gabryjonczyk ... Timm Maier
    Binding of STIL to PLK4's characteristic Polo-box 3 links PLK4 kinase activation to STIL self-association and is a crucial regulatory step for the localized recruitment of downstream factors in centriole duplication.
    1. Chromosomes and Gene Expression

    Regulation of chromatin architecture by transcription factor binding

    Stephanie Portillo-Ledesma, Suckwoo Chung ... Tamar Schlick
    The binding of transcription factors to mesoscale chromatin fibers leads to microdomains whose features are dependent on the linker DNA length, linker histone density, and tail acetylation levels.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments

    Scott D Hansen, R Dyche Mullins
    Lamellipodin, an important regulator of cytoskeletal and assembly cell migration, enhances the activity of Ena/VASP family actin polymerases by clustering them on leading-edge membranes and tethering them to actin filaments.

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