786 results found
    1. Epidemiology and Global Health

    The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa

    Thomas S Churcher, Natalie Lissenden ... Hilary Ranson
    Mosquitoes with high levels of pyrethroid resistance reduce the ability of bednets to protect those using them and the wider community, which is predicted to substantially increase malaria cases.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes

    Fangfei Qu, Damaris N Lorenzo ... Vann Bennett
    Ankyrin-B – through interactions with PI3P lipids, dynactin and RabGAP1L – functions as a critical node in the protein circuitry underlying polarized recycling of α5β1-integrin to enable haptotaxis along fibronectin gradients.
    1. Cell Biology

    Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized

    Danielle M Garshott, Elayanambi Sundaramoorthy ... Eric J Bennett
    A hierarchical relationship among highly conserved regulatory ribosomal ubiquitylation events and the presence of antagonistic deubiquitylating enzymes suggests a dynamic ubiquitin code impacts ribosome-associated activities.
    1. Neuroscience

    Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

    Margarita Calvo, Natalie Richards ... David LH Bennett
    Type 1 potassium channels alter their composition and localisation to suppress hyper-excitability and neuropathic pain of injured sensory neurons.
    1. Epidemiology and Global Health

    Spatio-temporal associations between deforestation and malaria incidence in Lao PDR

    Francois Rerolle, Emily Dantzer ... Adam Bennett
    Deforestation near villages is associated with short-term increases but long-term decreases in malaria incidence in Lao PDR, highlighting the influence of forest-going populations on malaria transmission in the region.
    1. Neuroscience

    The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans

    Michael J Iannacone, Isabel Beets ... David M Raizen
    During sickness, sleep is induced by neuropeptides, which contain an amidated arginine-phenylalanine motif, acting in a neuroendocrine fashion on a G-protein coupled receptor called DMSR-1.
    1. Cell Biology

    Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue

    Theodore J Zwang, Rachel E Bennett ... Bradley T Hyman
    Conditions for multiplexed antibody labeling in mouse brain tissue translates to effective labeling in human brain tissue when samples are prepared similarly.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of diverse membrane target recognitions by ankyrins

    Chao Wang, Zhiyi Wei ... Mingjie Zhang
    The 24 ankyrin repeats of ankyrin proteins form an extended solenoid that provides an extremely conserved groove for binding to numerous targets via combinatorial usage of multiple weak interaction sites.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    EDF1 coordinates cellular responses to ribosome collisions

    Niladri K Sinha, Alban Ordureau ... Rachel Green
    Endothelial Differentiation Factor 1 (EDF1) plays a critical role in driving mRNA-specific quality control and global transcriptional responses in response to ribosome collisions.
    1. Epidemiology and Global Health

    National and regional seasonal dynamics of all-cause and cause-specific mortality in the USA from 1980 to 2016

    Robbie M Parks, James E Bennett ... Majid Ezzati
    All parts of the USA are similarly adapted to temperature seasonality, although mortality seasonality, and how it has changed since the 1980s, depend on age and sex.

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