Local tissue hypoxia follows seizures, is responsible for postictal behavioural dysfunction rather than the seizures per se and can be treated.

Loss of myelin integrity in the mouse forebrain perturbs executive functions, assessed by tests requiring normal motor performance.

Cold detecting thermoreceptor TRPM8's signalling is diminished with ageing which leads to an impaired response to cold observed in ageing.

Virtual lesions of the left posterior inferior frontal gyrus in patients with lesions in the left temporo-parietal cortex disrupt phonologial decisions and lead to compensatory upregulation of the lesion homologue.

Analysis of performance on a novel behavioural paradigm investigating active information gathering reveals that subjective cognitive impairment is associated with hyperreactivity to uncertainty and links this mechanism to the affective burden in the condition and heightened insular-hippocampal connectivity.

Children with autism often 'tune out' the voices in their environment and new results show that impaired processing of voices in the brain's reward system may underlie this social behavior.

The endoplasmic reticulum (ER)-resident protein wolframin regulates MCT1 protein levels in retinal glial cells controlling the shuttling of energy metabolites to both somata and axons of retinal ganglion cells and, thus, supporting their fitness and survival.

The enduring impacts of early-life seizures on cognition and behavior are not attributed to neuronal loss but to disrupted hippocampus-prefrontal cortex network dynamics, heightened neuroinflammation, and altered dopaminergic transmission.

Endolysosmal trafficking defects, expansion of lysosomes, elevation of ceramides, and disruption of mitochondria are root causes of INAD/PARK14.