Hysteretic switching between virulence states has been observed in a human pathogen.

Yeast cells can tune the modality of a nutrient response on physiological and evolutionary timescales by adapting the expression and sequence of a sensor protein.

Sequencing and counting RNAs from single cells can create a misleading picture of alternative splicing if too many mRNAs are lost in the process.

Ubiquitous transcriptional factor-CBP/p300 interaction induces epigenetic and transcriptional bimodality, which can be utilized to tune mean gene expression and noise independently.

Transcriptomes of cells in the Drosophila visual system combined with anatomy and other information reveal new functional insight into the visual circuit.

Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.

The zinc finger protein ZBTB20 is a morning and evening activity gating factor in mice.

Embryonic gene expression is strongly influenced by maternal genetic variation and by embryonic variation that acts in cis but not in trans.

A combined experimental and modeling approach provides insight into potential biases when inferring transcription rates from static mRNA distributions, and shows that correcting for cell-cycle phase and post-transcriptional noise provides rates that agree with live-cell transcription measurements.

Despite their extreme morphologies, snakes display a global regulatory strategy of their Hox genes similar to that implemented by mammals with, however, important modifications in enhancer specificity.