2,206 results found
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

    Christopher T Boughter, Marta T Borowska ... Erin J Adams
    A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Method development and characterisation of the low-molecular-weight peptidome of human wound fluids

    Mariena JA van der Plas, Jun Cai ... Artur Schmidtchen
    Peptidomics method development and analysis of qualitative differences of peptide patterns in human wound fluids provide potential biomarkers for wound healing and infection.
  1. code and servers

    HPC4Africa: Open bioinformatics for Africa

    Towards a blueprint for a High Performance Computing infrastructure for African bioinformatics research.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C

    Thomas Hansen, Jocelyn Lee ... Peter L Davies
    Self-assembly of bacterial ice nucleation proteins is required for efficient activity and is mediated by electrostatic interactions, creating long and thin fibres.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural determinants of nuclear export signal orientation in binding to exportin CRM1

    Ho Yee Joyce Fung, Szu-Chin Fu ... Yuh Min Chook
    Some nuclear export signals (NESs) bind to the transport receptor CRM1 in the opposite orientation to those previously studied.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

    Wen Ma, Kevin D Whitley ... Klaus Schulten
    Integration of structural bioinformatics and free-energy simulations reveals how a helicase switches its function from unwinding to rezipping DNA, during which a key metastable conformation is predicted and verified by single-molecule measurements.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A structural model of the active ribosome-bound membrane protein insertase YidC

    Stephan Wickles, Abhishek Singharoy ... Roland Beckmann
    A cryo-EM structure combined with bioinformatics provide a structural view on a conserved co-translational membrane protein biogenesis pathway.
    1. Microbiology and Infectious Disease

    The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis

    Anat Melamed, Hiroko Yaguchi ... Charles RM Bangham
    The human leukemia virus HTLV-1 causes abnormal chromatin looping in tens of thousands of infected T cell clones in each host, and abnormal host transcription both flanking the integrated provirus and at distant loci in cis.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

    Nan Wang, Jing He ... Kehkooi Kee
    The lncRNA landscapes in human germ cells are comprehensively profiled and the functional role of an lncRNA LNC1845 in regulating gene expression of a neighboring coding gene LHX8 is elucidated.
    1. Ecology
    2. Microbiology and Infectious Disease

    Freshwater monitoring by nanopore sequencing

    Lara Urban, Andre Holzer ... Maximilian R Stammnitz
    From now on, nanopore metagenomics can be used to monitor aquatic environments with high spatiotemporal resolution, by use of a benchmarked, standardised and cost-effective workflow.

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