2,097 results found
    1. Cell Biology
    2. Physics of Living Systems

    Cell-scale biophysical determinants of cell competition in epithelia

    Daniel Gradeci, Anna Bove ... Guillaume Charras
    Mechanical competition is controlled by biophysical parameters that regulate cellular homeostatic density, while biochemical competition is regulated by parameters that influence the organisation of cells in a tissue.
    1. Neuroscience

    Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s

    Viktor J Olah, Annie M Goettemoeller ... Matthew JM Rowan
    Electrophysiological and genetic analyses reveal a biophysical mechanism in parvalbumin interneurons, uncoupled from changes in gene expression, resulting in reduced cortical inhibition in early-stage Alzheimer's disease.
    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Computational and Systems Biology
    2. Neuroscience

    Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics

    Jonathan Oesterle, Christian Behrens ... Philipp Berens
    Bayesian simulator-based inference is used to infer the parameters of complex multicompartment models of retinal neurons from two-photon imaging data.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

    Andrei Vovk, Chad Gu ... Anton Zilman
    Simple biophysical considerations explain the collective behavior of molecularly diverse complex protein assemblies that regulate transport between the nucleus and the cytoplasm in eukaryotic organisms.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions

    Christopher T Boughter, Martin Meier-Schellersheim
    A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A simple biophysical model emulates budding yeast chromosome condensation

    Tammy MK Cheng, Sebastian Heeger ... Frank Uhlmann
    A computational model of a yeast chromosome, based on first principles, recapitulates in vivo chromosome behavior, and thus provides unprecedented insight into what the inside of a chromosome is likely to look like.
    1. Physics of Living Systems

    Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila

    Myron Barber Child VI, Jack R Bateman ... Hernan G Garcia
    Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

    Kira M Düsterwald, Christopher B Currin ... Joseph V Raimondo
    Mathematical models with experimental validation show that chloride transporters in the cell membrane, and not negatively charged impermeant molecules, generate the driving force used by GABA receptors to silence neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex

    Atle E Rimehaug, Alexander J Stasik ... Anton Arkhipov
    A biophysically detailed model of mouse primary visual cortex reproduces, in a quantitative manner, experimentally recorded spikes and local field potentials, and suggests mechanisms that form current sinks and sources in vivo.

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