612 results found
    1. Ecology
    2. Evolutionary Biology

    Point of View: Towards a mechanistic foundation of evolutionary theory

    Michael Doebeli, Yaroslav Ispolatov, Burt Simon
    A description of evolution that is based on birth-death processes, and in which fitness is at most a derived quantity, is advocated.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles

    Rossana Droghetti, Nicolas Agier ... Marco Cosentino Lagomarsino
    Mathematical modeling and data analysis show that, over evolutionary times, the yeast temporal program of replication strives to avoid stalling events and minimize interference between neighbor origins.
    1. Evolutionary Biology
    2. Cancer Biology

    Evolutionary dynamics of cancer in response to targeted combination therapy

    Ivana Bozic, Johannes G Reiter ... Martin A Nowak
    A study that models the evolution of drug resistance in tumors reveals that drugs are more effective when given in combination than sequentially, and that cure is much more likely when the drugs target different pathways.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

    Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad
    Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.
    1. Computational and Systems Biology

    Evolutionary dynamics of incubation periods

    Bertrand Ottino-Loffler, Jacob G Scott, Steven H Strogatz
    Evolutionary graph theory solves the longstanding puzzle of why diverse infectious diseases and cancers show similar (approximately lognormal) distributions of their incubation periods.
    1. Neuroscience

    Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process

    Jean-Claude Platel, Alexandra Angelova ... Harold Cremer
    Adult neurogenesis in the olfactory bulb is not a turnover system but represents a lifelong neuronal addition mechanism.
    1. Evolutionary Biology

    Coupling adaptive molecular evolution to phylodynamics using fitness-dependent birth-death models

    David A Rasmussen, Tanja Stadler
    A new model describes how adaptive molecular evolution shapes phylogenetic trees and can be used to estimate the fitness effects of mutations from phylogenies.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston, Joerg P Burgstaller ... Nick S Jones
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Ecology
    2. Epidemiology and Global Health

    Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

    Cara E Brook, Mike Boots ... Anieke van Leeuwen
    Bats' uniquely robust innate antiviral immune defenses select for faster transmitting viruses likely to generate extreme virulence upon spillover to secondary hosts with immune systems divergent from those of bat.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Understanding drivers of phylogenetic clustering and terminal branch lengths distribution in epidemics of Mycobacterium tuberculosis

    Fabrizio Menardo
    Populations of Mycobacterium tuberculosis associated with clustering and shorter terminal branches are not necessarily transmitting more.

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