23 results found
    1. Cell Biology
    2. Developmental Biology

    A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea

    Arzu Öztürk-Çolak, Bernard Moussian ... Jordi Casanova
    Cell-cell junctions and the actin cytoskeleton are key players in the organisation and patterning of the extracellular matrix (ECM) on the apical side of tracheal cells.
    1. Immunology and Inflammation

    TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections

    Hannah P Savage, Kathrin Kläsener ... Nicole Baumgarth
    B-1 cell unresponsiveness to antigen-stimulation is overcome during infections when Toll-like receptor engagement removes negative regulators of B cell receptor signaling, thereby supporting B-1 cell differentiation to IgM-secreting plasmablasts.
    1. Immunology and Inflammation

    The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function

    Shasha Li, Michael D Bern ... Wayne M Yokoyama
    Deficiency of the transcriptional repressor, Bach2, results in more mature mouse natural killer cells.
    1. Biochemistry and Chemical Biology

    The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression

    Chunjing Bian, Qiang Chen, Xiaochun Yu
    Repression of gene expression by the histone methyltransferase G9a is guided by two zinc finger proteins that can recognize consensus sequences in DNA.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

    Carlos-Henrique D Barbosa, Fábio B Canto ... Maria Bellio
    Cytotoxic CD4 T lymphocytes are abundantly generated in T. cruzi-infected mice, predominantly infiltrate infected hearts, depend on T-cell intrinsic IL-18R/MyD88 signaling for expansion and their blood frequency correlates with the severity of chronic myocarditis in patients with Chagas disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1

    Mathew Clement, Kristin Ladell ... Ian R Humphreys
    The results presented here indicate that IL-10-producing CD4+ T cells express genes associated with chronically activated TH1-like cells, undergo clonal expansion, and inhibit antiviral T cell responses via the secretion of arginase-1, facilitating viral persistence in mice infected with MCMV.
    1. Developmental Biology
    2. Genetics and Genomics

    Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim

    Elizabeth M Knapp, Wei Li ... Jianjun Sun
    Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.
    1. Immunology and Inflammation

    Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

    Pedro P Cunha, Eleanor Minogue ... Randall S Johnson
    Oxygen levels at the time of T cell activation are major determinants of function, even when T cells are subsequently expanded in high levels of oxygen.
    1. Immunology and Inflammation

    Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

    Heng-Yi Chen, Ana Almonte-Loya ... Chan-Wang Jerry Lio
    Vitamin C supports the differentiation of antibody-secreting cells by remodeling the DNA methylome to enhance STAT3 DNA binding.
    1. Immunology and Inflammation

    Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

    Alexandria C Wells, Keith A Daniels ... Leonid A Pobezinsky
    TCR-mediated downregulation of let-7 microRNAs licenses the differentiation of activated CD8 T cells into cytotoxic T lymphocytes.

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