David Florentino Montez, Finnegan J Calabro, Beatriz Luna
The excessive behavioral variability associated with adolescence is the result of greater instability of widespread or global gain signals which produces greater variability in the amplitude of expression of whole-brain states of task-related activity.
Patrick G Bissett, McKenzie P Hagen ... Russell A Poldrack
Problematic design features in the stop-signal task for the massive Adolescent Brain Cognitive Development (ABCD) study undermine analyses of the shared data, but can be mitigated with proposed solutions.
Label-free three-photon imaging of whole, uncleared intact organoids generated from Rett syndrome patients show shorter migration distances and slower migration speeds of mutant radially migrating neurons with more tortuous trajectories.
Anders Martin Fjell, Hakon Grydeland ... Kristine Beate Walhovd
Volumetric lifespan change in subcortical structures follows fundamental principles of brain development, lifespan continuity, genetic organization, and age-invariant relationships to cognition.
Kristine B Walhovd, Stine K Krogsrud ... Didac Vidal-Pineiro
Greater early developmental growth, as indexed by birth weight, relates to greater cortical volume and area in a stable way through the human lifespan.
Miguel Ramirez, Yuliya Badayeva ... Daniel Goldowitz
An analysis of enhancer activity during mouse cerebellar development provides an invaluable resource for studying gene expression regulation by enhancers in the developing cerebellum and delivers a rich dataset of novel gene-enhancer associations providing a basis for future in-depth studies.
Diurnal variation loss of pineal allopregnanolone synthesis by light-at-night induces pituitary adenylate cyclase-activating polypeptide (PACAP) reduction and transcriptional PACAP repression in the cerebellum, with subsequent Purkinje cell death.
Max van Lessen, Shannon Shibata-Germanos ... Stefan Schulte-Merker
The discovery of a unique brain lymphatic cell type in the zebrafish model will facilitate the study of embryonic development and physiology, an essential mission to understand how clearance of macromolecules impact neurological diseases.