3,953 results found
    1. Neuroscience

    Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice

    Jonathan S Schor, Isabelle Gonzalez Montalvo ... Alexandra B Nelson
    In a mouse model of Parkinson's disease, deep brain stimulation of the subthalamic nucleus disrupts movement-related neural activity in parallel with relieving motor symptoms.
    1. Neuroscience

    Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation

    Yu Huang, Anli A Liu ... Lucas C Parra
    Direct in-vivo measurements in the human brain test validity of detailed computational models of trancranial electric stimulation and show that electric fields in the brain are weaker than currently assumed.
    1. Neuroscience

    Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models

    James J Bonaiuto, Archy de Berker, Sven Bestmann
    Residual activity from previous trials in a biophysical decision network model causes biases in choice behavior such that a previous response is more likely to be repeated.
    1. Medicine
    2. Neuroscience

    Lead-OR: A multimodal platform for deep brain stimulation surgery

    Simón Oxenford, Jan Roediger ... Andreas Horn
    Lead-OR visualizes results derived from microelectrode recordings in anatomical space, together with information derived from patient-specific MRI data, as well as high-resolution atlas resources during deep brain stimulation surgery.
    1. Medicine
    2. Neuroscience

    Instantaneous antidepressant effect of lateral habenula deep brain stimulation in rats studied with functional MRI

    Gen Li, Binshi Bo ... Xiaojie Duan
    Electrical stimulation at the lateral habenula causes an instantaneous remission of depressive symptoms in two rat models, with more medial stimulation sites exhibiting greater antidepressant effects than more lateral stimulation sites, as revealed by functional MRI studies.
    1. Neuroscience

    Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity

    Amy E Pohodich, Hari Yalamanchili ... Huda Y Zoghbi
    Forniceal deep brain stimulation is a promising treatment for several neuropsychiatric disorders as it upregulates synaptic and neurogenesis-associated genes, normalizes genes misregulated in Rett syndrome mice, and regulates genes altered in intellectual disability and major depression.
    1. Neuroscience

    Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

    Shaun R Patel, Todd M Herrington ... Emad N Eskandar
    Deep brain stimulation can selectively modify neural activity within the subthalamic nucleus to modify decisions under uncertainty in human subjects.
    1. Neuroscience

    Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

    Amanda M Brown, Joshua J White ... Roy V Sillitoe
    Genetic, pharmacologic, and optogenetic manipulations demonstrate that Purkinje cells can trigger and propagate the signals for tremor.
    1. Neuroscience

    ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

    Jormay Lim, Hsiao-Hsin Tai ... Jaw-Lin Wang
    Mouse brain neurons response to transcranial ultrasound at the energy level of 5 mW/cm2 and repeated stimulations lead to neurogenesis while ASIC1a is required both in vitro and in vivo as one of the mechanoreceptors.
    1. Neuroscience

    Externally induced frontoparietal synchronization modulates network dynamics and enhances working memory performance

    Ines R Violante, Lucia M Li ... David J Sharp
    Externally induced synchronous/desynchronous oscillations during working memory performance reveal distinct patterns of brain activity and connectivity across large-scale networks recruited by the task.

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