698 results found
    1. Neuroscience

    State-dependent brainstem ensemble dynamics and their interactions with hippocampus across sleep states

    Tomomi Tsunematsu, Amisha A Patel ... Shuzo Sakata
    Sub-second pontine waves functionally interact with hippocampal population activity in a state-dependent manner across sleep states, while brainstem ensemble dynamics exhibit slow, long-lasting state-predictive activity.
    1. Neuroscience

    Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

    Melissa J Polonenko, Ross K Maddox
    The response from discrete stages of the early auditory pathway can be measured by subtle manipulations to long-form natural speech stimuli paired with deconvolution analysis of electroencephalography data.
    1. Neuroscience

    Opioids depress breathing through two small brainstem sites

    Iris Bachmutsky, Xin Paul Wei ... Kevin Yackle
    Opioids stop breathing during overdose by silencing two small brain sites, with just 140 neurons in the breathing rhythm generator exerting the key effect.
    1. Neuroscience

    The human auditory brainstem response to running speech reveals a subcortical mechanism for selective attention

    Antonio Elia Forte, Octave Etard, Tobias Reichenbach
    Selective attention to one of two speakers consistently modulates the response of the human auditory brainstem to each speaker's pitch.
    1. Neuroscience

    Dynamic modulation of decision biases by brainstem arousal systems

    Jan Willem de Gee, Olympia Colizoli ... Tobias H Donner
    Rapid increases in the brain’s level of alertness, or arousal, contribute to variability in decision making by reducing existing biases.
    1. Computational and Systems Biology
    2. Neuroscience

    CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

    David Forsberg, Zachi Horn ... Eric Herlenius
    Novel brainstem organotypic cultures that generate rhythmic respiratory motor activity reveal the neural networks that control breathing and a new pathway in the hypercapnic response.
    1. Neuroscience

    Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia

    Valeria Oliva, Ron Hartley-Davies ... Jonathan CW Brooks
    Attention-grabbing tasks produce rapid opioid-mediated analgesia via the descending pain modulation network to alter spinal neuronal activity.
    1. Neuroscience

    Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome

    Irene Bolea, Alejandro Gella ... Albert Quintana
    Glutamatergic brainstem neurons drive motor and respiratory deficits, and GABAergic basal ganglia neurons cause hypothermia and fatal epileptic events, in a model of mitochondrial disease.
    1. Neuroscience

    The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

    Amy A Worth, Rosemary Shoop ... Simon M Luckman
    The GDF15 receptor, GFRAL,is expressed on a unique population of brainstem CCK neurons and mediates pathophysiological anorexia.
    1. Neuroscience

    Principal cells of the brainstem’s interaural sound level detector are temporal differentiators rather than integrators

    Tom P Franken, Philip X Joris, Philip H Smith
    Principal neurons of the brainstem nucleus comparing sound level at the two ears do not have the slow response properties previously attributed to them, but are instead specialized for fast weighing of excitation and inhibition.

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