95 results found
    1. Cell Biology
    2. Neuroscience

    A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

    Sonal Nagarkar-Jaiswal, Pei-Tseng Lee ... Hugo J Bellen
    A large collection of functional EGFP tagged proteins derived from MiMIC insertions allows examination of protein expression in unfixed tissues and efficient tissue specific reversible knock down of proteins.
    1. Neuroscience

    Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity

    William D Constance, Amrita Mukherjee ... Darren W Williams
    Axonal arborisation growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin that provide stability for filopodia, enabling a 'stick and grow'-based mechanism, wholly independent of synapse formation.
    1. Neuroscience

    A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones

    Matthias Siebert, Mathias A Böhme ... Stephan J Sigrist
    High affinity interactions with transport adaptors are important to shield the interaction surfaces of cytomatrix components to block fatal premature oligomerization of active zone proteins during axonal transport.
    1. Developmental Biology

    Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons

    Amira Hassan, Pablo Araguas Rodriguez ... Tony D Southall
    The condensin I subunit Cap-G is expressed in post-mitotic neurons and its removal, especially from less mature neurons, results in gene expression changes, reduced survival and behavioural defects in Drosophila.
    1. Neuroscience

    A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster

    Paula R Haynes, Bethany L Christmann, Leslie C Griffith
    Dorsal paired medial neurons, which are required for memory consolidation, promote sleep by inhibiting the excitation of mushroom body neurons.
    1. Neuroscience

    The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling

    Drew Stenesen, Andrew T Moehlman, Helmut Krämer
    Fly vision depends on a member of the SLC22 transporter family for recycling the histamine neurotransmitter following its uptake by glia and its modification into the transport metabolite carcinine.
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    1. Genetics and Genomics
    2. Neuroscience

    Circadian programming of the ellipsoid body sleep homeostat in Drosophila

    Tomas Andreani, Clark Rosensweig ... Ravi Allada
    The circadian clock gates sleep drive by modulating sleep homeostat neurons.
    1. Neuroscience

    Rapid cell type-specific nascent proteome labeling in Drosophila

    Stefanny Villalobos-Cantor, Ruth M Barrett ... Ian Martin
    Newly-synthesized protein can be labeled with cellular specificity in Drosophila brain using the puromycin analog PhAc-OPP coupled to expression of the unblocking enzyme PGA in a tissue or cell type of interest.
    1. Neuroscience

    Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner

    Zhuo Guan, Monica C Quiñones-Frías ... J Troy Littleton
    Drosophila synaptotagmin 7 functions to restrict SV availability and release, but does not act as the Ca2+ sensor mediating the asynchronous release and facilitation remaining in synaptotagmin 1 mutants.
    1. Neuroscience

    Regulation of presynaptic Ca2+ channel abundance at active zones through a balance of delivery and turnover

    Karen L Cunningham, Chad W Sauvola ... J Troy Littleton
    Voltage-gated calcium channel delivery to synaptic active zones (AZs) occurs broadly across the population, correlates with AZ size, and is regulated by α2δ, while channel recycling is promoted by new delivery to generate an upper limit on AZ accumulation.

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