2,562 results found
    1. Epidemiology and Global Health

    Disentangling the rhythms of human activity in the built environment for airborne transmission risk: An analysis of large-scale mobility data

    Zachary Susswein, Eva C Rest, Shweta Bansal
    Fine-grain mobility data empirically quantify the propensity for human mixing to be indoors across the US and improve understanding of the relationship between the physical environment and infection risk in light of global change.
    1. Ecology
    2. Microbiology and Infectious Disease

    Mapping microbial ecosystems and spoilage-gene flow in breweries highlights patterns of contamination and resistance

    Nicholas A Bokulich, Jordyn Bergsveinson ... David A Mills
    Mapping microbial landscapes in indoor environments can predict how contaminants and spoilage resistance genes propagate within food-production environments, yielding novel insight for controlling spoilage.
    1. Neuroscience

    RatInABox, a toolkit for modelling locomotion and neuronal activity in continuous environments

    Tom M George, Mehul Rastogi ... Caswell Barry
    A new python package standardises and simplifies how spatial behaviour and neural representations are modelled in continuous environments.
    1. Physics of Living Systems

    Dynamics of cooperative excavation in ant and robot collectives

    S Ganga Prasath, Souvik Mandal ... L Mahadevan
    Observations of ant excavation from a confining corral, along with theoretical models and synthetic robot experiments show the emergence of cooperation induced by pheromones in a malleable environment that is moulded by and moulds collective behavior.
    1. Ecology
    2. Microbiology and Infectious Disease

    A diverse host thrombospondin-type-1 repeat protein repertoire promotes symbiont colonization during establishment of cnidarian-dinoflagellate symbiosis

    Emilie-Fleur Neubauer, Angela Z Poole ... Virginia M Weis
    The colonization of corals and their relatives by intracellular microalgae is facilitated by immunity proteins in the animal that contain thrombospondin-type-1 repeats, elucidating the inter-partner recognition processes required for the establishment of this ecologically important symbiosis.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Unifying the known and unknown microbial coding sequence space

    Chiara Vanni, Matthew S Schechter ... Antonio Fernàndez-Guerra
    A newly developed computational framework provides an overview of the extent, diversity, and relevance of the genes of unknown function in genomes and metagenomes.
    1. Microbiology and Infectious Disease

    eDNA-stimulated cell dispersion from Caulobacter crescentus biofilms upon oxygen limitation is dependent on a toxin–antitoxin system

    Cecile Berne, Sébastien Zappa, Yves V Brun
    Genetic and microscopy analyses identify a programmed cell death mechanism that kills a cell subpopulation in a bacterial biofilm where oxygen is limiting, thereby promoting dispersion of newborn motile cells through the action of DNA released by dead cells.
    1. Evolutionary Biology

    Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

    Grant Kinsler, Kerry Geiler-Samerotte, Dmitri A Petrov
    A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis

    Lukas P Feilen, Shu-Yu Chen ... Harald Steiner
    Biochemical studies in combination with computational modeling and molecular dynamics simulations reveal that the lipid bilayer promotes intramembrane proteolysis by stabilizing the enzyme-substrate complex and the protease active site.
    1. Neuroscience

    A naturalistic environment to study visual cognition in unrestrained monkeys

    Georgin Jacob, Harish Katti ... SP Arun
    A novel naturalistic environment with a touchscreen enables high-quality eye tracking for studying visual cognition in monkeys, and allows naive monkeys to learn complex tasks through a combination of social observation of trained monkeys and trial-and-error learning.

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