230 results found
    1. Developmental Biology
    2. Evolutionary Biology

    A shift in anterior–posterior positional information underlies the fin-to-limb evolution

    Koh Onimaru, Shigehiro Kuraku ... Mikiko Tanaka
    A shift in antero-posterior positional information may contribute to the fin-to-limb transformation.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Kinesin motility is driven by subdomain dynamics

    Wonmuk Hwang, Matthew J Lang, Martin Karplus
    The motor protein kinesin utilizes its fuel molecule by active and concerted motions of its subdomains, while it rapidly interacts with the microtubule track by forming a wet and dynamic interface.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

    Ali H Alghamdi, Jane C Munday ... Harry P De Koning
    Study of TbAQP2 adaptations and substrate interactions shows how this aquaglyceroporin enables cellular entry of large antimicrobial agents in Trypanosoma brucei.
    1. Structural Biology and Molecular Biophysics

    Examining kinesin processivity within a general gating framework

    Johan OL Andreasson, Bojan Milic ... Steven M Block
    A general framework for gating reveals that inter-head tension is not essential for coordinating kinesin stepping, and that neck-linker length is tuned to enhance processivity and velocity.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

    Konstadinos Moissoglu, Kyota Yasuda ... Stavroula Mili
    RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

    Zhiyun Ge, Bao Lin Quek ... J Robert Hogg
    The RNA-binding protein PTBP1 is recruited to sites near stop codons in retroviral and human mRNAs, shielding them from detection and degradation by the nonsense-mediated mRNA decay pathway.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Engineering a conserved RNA regulatory protein repurposes its biological function in vivo

    Vandita D Bhat, Kathleen L McCann ... Zachary T Campbell
    Motif length plays a critical role in the specification of biological function within a conserved family of RNA-binding proteins.
    1. Physics of Living Systems

    High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine

    Asher Preska Steinberg, Sujit S Datta ... Rustem F Ismagilov
    Polymers from dietary fiber can control the aggregation of particulates in the murine small intestine in a manner qualitatively consistent with depletion interactions.
    1. Genetics and Genomics

    A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition

    Tyler C Detomasi, Adriana M Rico-Ramírez ... N Louise Glass
    Allorecognition in Neurospora crassa requires CWR-1 (cell wall remodeling protein), an essential process that ensures identity of an interconnected fungal syncytial colony and requires the CWR-1 polysaccharide monooxygenase domain, but not its catalytic activity.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data

    James W Opzoomer, Jessica A Timms ... Shahram Kordasti
    ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.

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