15,395 results found
    1. Neuroscience

    Cerebellar patients have intact feedback control that can be leveraged to improve reaching

    Amanda M Zimmet, Di Cao ... Noah J Cowan
    A control system model of cerebellar patients' movements provides insight into the cerebellum's role in reaching and informs a virtual reality intervention to improve patient reaches.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870

    Ye Zhou, Can Cao ... Xuejun Cai Zhang
    The structure of receptor-ligand complex reveals the ligand binding selectivity among different dopamine receptor subtypes and also shows how this ligand class inhibits receptor activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

    Moitrayee Bhattacharyya, Margaret M Stratton ... John Kuriyan
    Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase

    David R Lorenz, Lauren F Meyer ... Hugh P Cam
    Set1 has roles in chromatin organization and transcriptome control that are largely independent of histone H3 lysine 4 methylation.
    1. Neuroscience

    Internally generated time in the rodent hippocampus is logarithmically compressed

    Rui Cao, John H Bladon ... Marc W Howard
    Receptive fields for time in the hippocampus, like receptive fields for retinal space and receptive fields for numerosity, obey the Weber-Fechner law.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Radiocarbon and genomic evidence for the survival of Equus Sussemionus until the late Holocene

    Dawei Cai, Siqi Zhu ... Yu Jiang
    The first nuclear genomes of the Equus (Sussemionus) ovodovi enable us to reconstruct the speciation and extinction trajectory of this lineage.
    1. Neuroscience

    A spatial-attentional mechanism underlies action-related distortions of time judgment

    Liyu Cao
    The distribution of visuospatial attention shapes the timing report results obtained with the Libet clock method, thus explaining the temporal binding effect in this context.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

    Wesley L Cai, Jocelyn Fang-Yi Chen ... Qin Yan
    The chromatin regulator WDR5 is a regulator of translation, and small molecule inhibitors or degraders of WDR5 can be used to treat triple-negative breast cancer.
    1. Chromosomes and Gene Expression

    Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

    Mark C Johnson, Geylani Can ... Philip Zegerman
    The S-phase checkpoint has roles in all phases of the cell cycle, which has implications for the majority of cancers that lack cell cycle controls.
    1. Neuroscience

    Minian, an open-source miniscope analysis pipeline

    Zhe Dong, William Mau ... Denise J Cai
    Minian is an open-source analysis pipeline for calcium imaging data that enhances usability with low memory demands and transparency with user-friendly interactive visualizations.

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