Helitron transposable elements, by providing high density transcription factor binding sites upstream of host genes, have diversified the heat shock response within and among Caenorhabditis species.

A broad mutational target is the cause of the high mutational variance and corresponding fast phenotypic evolutionary rate in P3.p cell fate in Caenorhabditis nematodes.

The transcriptional cofactor HPK-1 (homeodomain-interacting protein kinase) functions as a key regulator of multiple proteostatic stress responses, each originating from discrete neuronal subtypes within the Caenorhabditis elegans nervous system to preserve neuronal health and maintain organismal proteostasis during normal aging.

Hawaiian Caenorhabditis elegans harbor high levels of genetic diversity that might represent the complex patterns of ancestral diversity in the species prior to human influence.

Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.

C. elegans foraging efficiently approximate maximally informative search strategies that involve abrupt switching between different types of behaviors.

Gene sharing through different isoforms can precede the formation of independent genes.

TARDIS enables efficient and diverse transgenesis in Caenorhabditis elegans by integrating synthetic DNA libraries into engineered genomic sites, rivaling the scale of transformation previously only possible in microbes.

Male C. elegans die through two distinct mechanisms – mating-induced germline activation, and potent male pheromone toxicity – but the latter is unique to males of androdioecious species (made up of hermaphrodites and males).

Regulatory hierarchies controlling sex determination and X-chromosome dosage compensation between closely-related nematode species are conserved, but X-chromosome target specificity for the condensin dosage compensation complex has diverged, thereby contributing to reproductive isolation.