1,415 results found
    1. Neuroscience

    Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

    Jeong Hyang Park, Chang Geon Chung ... Sung Bae Lee
    Genetic and optogenetic analyses in Drosophila neurons reveal calcium as one of the key regulators of nucleocytoplasmic localization of TDP-43 via Calpain-A and Importin α3.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of Ca2+ transport by ferroportin

    Jiemin Shen, Azaan Saalim Wilbon ... Yaping Pan
    Cryo-EM structure and functional analyses show that human iron exporter ferroportin (Fpn) can bind and transport calcium ions and the transport activity is reduced when the concentration of ferrous ions is high.
    1. Structural Biology and Molecular Biophysics

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

    Wenli Dai, Brigitte Laforest ... Christopher R Weber
    TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.
    1. Biochemistry and Chemical Biology

    Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

    Ming-Feng Tsai, Charles B Phillips ... Christopher Miller
    Studies of EMRE, one of the four essential protein subunits in the mitochondrial calcium uniporter complex that regulates calcium ion levels in mitochondria, reveal new details about the physical interactions between the subunits.
    1. Cell Biology

    Testing the ion-current model for flagellar length sensing and IFT regulation

    Hiroaki Ishikawa, Jeremy Moore ... Wallace F Marshall
    A model for flagellar length control based on calcium influx is rejected based on quantitative measurements in Chlamydomonas cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

    Charles B Phillips, Chen-Wei Tsai, Ming-Feng Tsai
    Biochemical analysis reveals molecular mechanisms underlying the activation of the mitochondrial Ca2+ uniporter by intracellular Ca2+ signals.
    1. Cell Biology

    Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo

    Joris P Nassal, Fiona H Murphy ... Matthijs Verhage
    In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.
    1. Developmental Biology
    2. Neuroscience

    Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling

    Marko Brankatschk, Sebastian Dunst ... Suzanne Eaton
    Yeast specific lipids promote the transport of lipid transfer protein (LTP) across the blood brain barrier to the neurons that regulate systemic insulin signaling.
    1. Immunology and Inflammation
    2. Neuroscience

    Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

    Sina C Rosenkranz, Artem A Shaposhnykov ... Manuel A Friese
    Inducing neuronal mitochondrial activity during central nervous system inflammation counteracts inflammation-induced neuronal electron transport chain deficiency and calcium toxicity, thereby protecting against neuronal loss in a multiple sclerosis mouse model.
    1. Computational and Systems Biology
    2. Neuroscience

    Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

    Adam C Lu, Christine Kyuyoung Lee ... Mark P Beenhakker
    A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.

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