Giuseppina Mastrototaro, Pierluigi Carullo ... Marie-Louise Bang
FHOD1 and CARP/Ankrd1 interact with the N-terminal region of palladin and cardiomyocyte-specific deletion of palladin in adult, but not embryonic, mice leads to dilated cardiomyopathy associated with intercalated disc widening.
Correlative imaging of the heart at multiple spatial scales has the potential to revolutionize the way we understand deficiencies in congenital heart disease.
Thomas Grandits, Christoph M Augustin ... Alexander Jung
Neural networks can emulate normal and abnormal human ventricular action potentials accurately and potentially much faster than regular simulations paving the way for more efficient quantitative systems pharmacology studies.
Catherine A Makarewich, Amir Z Munir ... Eric N Olson
Cardiac-specific overexpression of a recently discovered micropeptide, DWORF, enhances calcium cycling and contractility in the heart and rescues the heart failure phenotype of a genetic mouse model of dilated cardiomyopathy.
Matthew P Klassen, Christian J Peters ... Yuh Nung Jan
As in humans, Drosophila hearts are able to maintain contractile performance during healthy aging, but this maintenance is associated with an increased susceptibility to progressive dysrhythmias that can lead to fibrillatory arrest.
The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
Jean-François Darrigrand, Mariana Valente ... Bruno Cadot
New views on the relevance of bone morphogenetic protein signalling fine tuning in the cardiac neural crest cells for the heart outflow tract septation and the formation of the great arteries.