107 results found
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a mitochondrial ATP synthase with bound native cardiolipin

    Alexander Mühleip, Sarah E McComas, Alexey Amunts
    The atomic model of a mitochondrial ATP synthase dimer underlies functions of its specific protein constituents and boundary cardiolipins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro

    Saranya Subramani, Harmonie Perdreau-Dahl, Jens Preben Morth
    A magnesium transporter from Escherichia coli depends strongly on the lipid cardiolipin and acts both as a sensor and a transporter of magnesium.
    1. Cell Biology

    Cardiolipin targets a dynamin-related protein to the nuclear membrane

    Usha Pallabi Kar, Himani Dey, Abdur Rahaman
    A single amino acid residue is critical for cardiolipin interaction specificity and nuclear membrane recruitment of a dynamin-related protein.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture

    Max Emanuel Harner, Ann-Katrin Unger ... Walter Neupert
    Interactions between Aim24 and the mitochondrial outer and inner membrane contact site complex (MICOS) are essential for mitochondrial ultrastructure, lipid composition and oxidative phosphorylation.
    1. Microbiology and Infectious Disease

    Insect endosymbiont proliferation is limited by lipid availability

    Jeremy K Herren, Juan C Paredes ... Bruno Lemaitre
    The endosymbiont Spiroplasma can only proliferate if it can acquire sufficient hemolymph lipids from its insect host.
    1. Cell Biology

    MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

    Jonathan R Friedman, Arnaud Mourier ... Jodi Nunnari
    A conserved mitochondrial inner membrane complex called MICOS works together with the mitochondrial lipid cardiolipin and respiratory complexes to direct the position, copy number and stabilization of cristae structures for efficient respiration.
    1. Cell Biology

    Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

    Albert Pérez-Martí, Suresh Ramakrishnan ... Matias Simons
    Monounsaturated fatty acids protect against DKD by enhancing membrane fluidity and decreasing ER lipid bilayer stress in renal proximal tubules.
    1. Structural Biology and Molecular Biophysics

    Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

    Yifan Ge, Xiaojun Shi ... Luke H Chao
    An in vitro reconstitution assay reveals stoichiometric levels of the short form of Opa1 work together with the long form of Opa1 to mediate efficient and fast membrane pore opening.
    1. Cell Biology

    QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

    Virginia Guarani, Elizabeth M McNeill ... J Wade Harper
    A comprehensive analysis of the human MICOS complex has identified a novel subunit called QIL1 that is required for cristae junction formation in human cells and Drosophila, through its role in the assembly of the MICOS complex.
    1. Cell Biology

    Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

    Mario Ruiz, Rakesh Bodhicharla ... Marc Pilon
    Silencing the acyl-coA synthethase ACSL1 protects against saturated fat lipotoxicity by preventing the degradation of polyunsaturated fatty acids, allowing them to be incorporated into phospholipids and improves membrane fluidity.

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