128 results found
    1. Cell Biology
    2. Developmental Biology

    Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

    Yfat Yahalom-Ronen, Dana Rajchman ... Eldad Tzahor
    Compliant matrix provides a permissive micoenvironment for cardiomyocyte dedifferentiation, cell division and expansion, and thus may open a new avenue towards cardiac regeneration.
    1. Developmental Biology

    Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

    Roberto Quaranta, Jakob Fell ... Boris Greber
    Loss and gain-of-function investigation uncovers a regulatory network controlling human heart chamber specification in which the cardiac precursor gene ISL1 accelerates ventricular induction and antagonizes retinoic acid-driven atrial commitment.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

    Valeria Taliani, Giulia Buonaiuto ... Monica Ballarino
    The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
    1. Developmental Biology

    SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients

    Fei Liang, Bo Wang ... Zhen Zhang
    Combined evidence of human genetics, in vitro cardiomyocyte differentiation, and mouse model indicates that SORBS2 is a regulator of second heart field development and its deficiency causes seemingly opposite atrial septal defects.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes

    Nicholas Strash, Sophia DeLuca ... Nenad Bursac
    Comparative analysis of cardiac mitogenic pathways identified a potent human gene that is effective at driving in vitro cell cycle activation across species and cell culture systems.
    1. Cell Biology
    2. Medicine

    SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients

    Eric N Jimenez-Vazquez, Michael Arad ... José Jalife
    Important mechanistic details on Duchenne Muscular Dystrophy arrhythmogenesis are revealed, providing a crucial lead for investigators interested in developing therapeutic solutions for this deadly disease.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser, Antonio MA Miranda ... Paul R Riley
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Cell Biology
    2. Developmental Biology

    Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

    David C Zebrowski, Silvia Vergarajauregui ... Felix B Engel
    Mammal hearts are unable to replace lost cardiomyocytes, which may be due to the loss of centrosome integrity in these cells after birth.
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    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    CHD-associated enhancers shape human cardiomyocyte lineage commitment

    Daniel A Armendariz, Sean C Goetsch ... Gary C Hon
    Single-cell screens during human cardiomyocyte (CM) differentiation reveal that perturbation of congenital heart defect-linked enhancers/genes causes deficient CM differentiation.
    1. Chromosomes and Gene Expression

    A promoter interaction map for cardiovascular disease genetics

    Lindsey E Montefiori, Debora R Sobreira ... Marcelo A Nóbrega
    Promoter capture Hi-C in human iPSCs and iPSC-derived cardiomyocytes provides a platform to interrogate gene-regulatory dynamics of cardiomyocyte differentiation and directly links thousands of cardiovascular disease risk loci to hundreds of distal target genes.

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