103 results found
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors

    Alba Timón-Gómez, Alexandra L Scharr ... Andy J Chang
    An atypical configuration of mitochondrial electron transport chain proteins may underlie the exquisite sensitivity of the carotid body to small decreases in oxygen availability.
    1. Developmental Biology

    HIF-2α is essential for carotid body development and function

    David Macias, Andrew S Cowburn ... Randall S Johnson
    Genetic and physiological analyses demonstrate the essential role of the transcription factor HIF-2alpha in the sympathetic nervous system control of the ventilatory response to hypoxia.
    1. Developmental Biology

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman, Alan J Burns ... Clare V H Baker
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
    1. Developmental Biology

    Correction: HIF-2α is essential for carotid body development and function

    David Macias, Andrew S Cowburn ... Randall Johnson
    1. Immunology and Inflammation
    2. Neuroscience

    Development and characterization of a chronic implant mouse model for vagus nerve stimulation

    Ibrahim T Mughrabi, Jordan Hickman ... Stavros Zanos
    Long-term, dose-controlled vagus nerve stimulation (VNS) is feasible in mice using a multi-lab validated implantation procedure, allowing therapeutic testing of VNS in many disease models.
    1. Developmental Biology

    Evolutionary Developmental Biology: Sensing oxygen inside and out

    Maria R Stupnikov, Wellington V Cardoso
    Neuroendocrine cells act as oxygen sensors in animals from fish to humans, but the evolutionary origins of these cells are only just becoming clear.
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    1. Neuroscience

    An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents

    Mitchell Bishop, Maximilian Weinhold ... Shahriar SheikhBahaei
    The introduced Python tool was used to characterize breathing behaviors of common marmosets in room air and acute hypoxic (10% O2) and hypercapnic (6% CO2) conditions.
    1. Computational and Systems Biology
    2. Medicine

    An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

    Amit Frishberg, Inge van den Munckhof ... Irit Gat-Viks
    A novel type of metabolic syndrome, derived from computational modeling of phenotypic diversity in normal physiological settings, increases the risk of certain complex diseases.
    1. Evolutionary Biology

    Neurocranial anatomy of an enigmatic Early Devonian fish sheds light on early osteichthyan evolution

    Alice M Clement, Benedict King ... John A Long
    Stunning new scan data of an enigmatic fish from the Early Devonian of Australia, Ligulalepis, is identified as a stem osteichthyan, specifically, as the sister taxon to the 'psarolepids' plus crown osteichthyans.
    1. Medicine

    Cardiovascular adaptation to hypoxia and the role of peripheral resistance

    Andrew S Cowburn, David Macias ... Randall S Johnson
    Radiotelemetric and genetic studies of peripheral tissue response show that a peripheral tissue can dynamically alter cardiovascular adaptation to changes in environmental oxygen.

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