A control system model of cerebellar patients' movements provides insight into the cerebellum's role in reaching and informs a virtual reality intervention to improve patient reaches.
High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.
A novel RNA-based trans-regulatory system that control gene expression in mammalian cells has been developed and they can be coupled to endogenous signals.
Jennifer A Honeycutt, Camila Demaestri ... Heather C Brenhouse
Early life adversity led to hyper-innervation from the basolateral amygdala to the prefrontal cortex earlier in females than males and disrupted maturation of functional connectivity, which predicted anxiety-like outcomes.
The structure of receptor-ligand complex reveals the ligand binding selectivity among different dopamine receptor subtypes and also shows how this ligand class inhibits receptor activity.
Moitrayee Bhattacharyya, Margaret M Stratton ... John Kuriyan
Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.
Dopamine neurons in medial versus lateral VTA encode different signals during fear extinction, yet inhibition of both populations influences fear extinction, at different times.
Targeting the activation of the androgen receptor N-terminal domain by the cochaperone Bag-1L provides a new approach for inhibiting androgen receptor function to treat prostate cancer.
