21 results found
    1. Cell Biology

    Cavin-3 dictates the balance between ERK and Akt signaling

    Victor J Hernandez, Jian Weng ... Peter Michaely
    Cavin-3 is a tumor suppressor protein that inhibits Akt signaling, suppresses Warburg metabolism, promotes apoptosis, and protects against cachexia.
    1. Cell Biology

    Cell Biology: A new regulator of caveolae signalling

    Alan J Whitmarsh
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    1. Cell Biology

    Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation

    Eline Lemerle, Jeanne Lainé ... Stéphane Vassilopoulos
    Caveolae and Bin1 form tubulation platforms.
    1. Cell Biology

    Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination

    Eric Seemann, Minxuan Sun ... Britta Qualmann
    Mice lacking the membrane-shaping protein syndapin III show severe reduction of caveolae reminiscent of human caveolinopathies but maintain plasma membrane-associated caveolar coats proteins and thereby unveil physiological impairments associated with lack of invaginated caveolae.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

    Yann Gambin, Nicholas Ariotti ... Robert G Parton
    New insights into the assembly and membrane interactions of the caveolar coat complex reveal the reversible association/dissociation of distinct subcomplexes onto the membrane, which differs from the assembly/disassembly of clathrin-coated pits.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges

    Libin Liu, Paul F Pilch
    PTRF (Cavin-1) mediates metabolism-regulated ribosomal transcription in mature adipocytes, independent of its role in caveolae formation.
    1. Cell Biology
    2. Genetics and Genomics

    Multiple motors cooperate to establish and maintain acentrosomal spindle bipolarity in C. elegans oocyte meiosis

    Gabriel Cavin-Meza, Michelle M Kwan, Sarah M Wignall
    Rapid depletion of dynein from oocytes yielded new insights into acentrosomal pole organization and also led to the first evidence that the kinesin-5 motor BMK-1 plays a role in microtubule organization during C. elegans meiosis.
    1. Cell Biology
    2. Physics of Living Systems

    Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

    Camille Morel, Eline Lemerle ... Emmanuel Lemichez
    Caveolin-1 controls the width of transendothelial cell tunnels via a direct or indirect effect on membrane bending rigidity.
    1. Cell Biology

    In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish

    Zherui Xiong, Harriet P Lo ... Thomas E Hall
    BLITZ system enables proximity-dependent biotin labelling in live zebrafish embryos with cell and tissue specificity, providing a versatile and valuable tool for proteomic discovery using the zebrafish model.
    1. Cancer Biology
    2. Cell Biology

    Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

    Kerrie-Ann McMahon, David A Stroud ... Robert G Parton
    Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.

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