Mice lacking the membrane-shaping protein syndapin III show severe reduction of caveolae reminiscent of human caveolinopathies but maintain plasma membrane-associated caveolar coats proteins and thereby unveil physiological impairments associated with lack of invaginated caveolae.
New insights into the assembly and membrane interactions of the caveolar coat complex reveal the reversible association/dissociation of distinct subcomplexes onto the membrane, which differs from the assembly/disassembly of clathrin-coated pits.
Gabriel Cavin-Meza, Michelle M Kwan, Sarah M Wignall
Rapid depletion of dynein from oocytes yielded new insights into acentrosomal pole organization and also led to the first evidence that the kinesin-5 motor BMK-1 plays a role in microtubule organization during C. elegans meiosis.
BLITZ system enables proximity-dependent biotin labelling in live zebrafish embryos with cell and tissue specificity, providing a versatile and valuable tool for proteomic discovery using the zebrafish model.
Kerrie-Ann McMahon, David A Stroud ... Robert G Parton
Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.