1,608 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

    Huasong Lu, Yuhua Xue ... Qiang Zhou
    A new potent and selective CDK9 inhibitor induces the expression of the proto-oncogene MYC via a mechanism that depends on the bromodomain protein BRD4.
    1. Cell Biology

    Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation

    Hee Won Yang, Steven D Cappell ... Tobias Meyer
    Application of a live-cell reporter for CDK4/6 activity reveals rapid activity changes and reversibility in the cell-cycle entry signaling program.
    1. Cancer Biology

    Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

    Mei Zeng, Nicholas P Kwiatkowski ... Nathanael S Gray
    A multi-transcriptional CDKs inhibitor suppresses MYC and induces regression of ovarian tumors, indicating that targeting CDK7, 12, 13 with THZ1 may be an effective approach for treating MYC-dependent malignancies.
    1. Cell Biology

    Cyclin-dependent kinase control of motile ciliogenesis

    Eszter K Vladar, Miranda B Stratton ... Jeffrey D Axelrod
    Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

    Emilia Dimitrova, Takashi Kondo ... Robert J Klose
    The ZF-CxxC protein FBXL19 recruits kinase-associated Mediator to CpG islands of silent developmental genes in embryonic stem cells, which primes these genes for activation during differentiation and is required for embryonic development.
    1. Cell Biology
    2. Computational and Systems Biology

    CDK control pathways integrate cell size and ploidy information to control cell division

    James Oliver Patterson, Souradeep Basu ... Paul Nurse
    DNA concentration, cyclin levels, phosphatase activity, and CDK phosphorylation combine to directly link cell size to cell division.
    1. Immunology and Inflammation

    Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

    Isaac J Jensen, Xiang Li ... Vladimir P Badovinac
    Sepsis leads to lasting changes in the composition of the pre-existing memory CD8 T cell compartment leading to altered localization, changes in their transcriptional landscape and chromatin accessibility, differential function, and reduced capacity to control infection.
    1. Computational and Systems Biology

    CDK9-dependent RNA polymerase II pausing controls transcription initiation

    Saskia Gressel, Björn Schwalb ... Patrick Cramer
    CDK9 inhibition in human cells uncovers that Pol II pause duration regulates the frequency of productive transcription initiation.
    1. Immunology and Inflammation

    TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

    Marije Baas, Alix Besançon ... Sylvaine You
    The interplay between the cytokine TGFβ and the PD-1/PD-L1 pathway promotes CD8+ T cell anergy and tolerance towards transplanted tissues.
    1. Cancer Biology
    2. Cell Biology

    Distinct states of nucleolar stress induced by anticancer drugs

    Tamara A Potapova, Jay R Unruh ... Jennifer L Gerton
    Anticancer compound library screen identified many types of nucleolar stress and revealed an essential role of transcriptional cyclin-dependent kinases in nucleolar structure and function.

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