2,386 results found
    1. Developmental Biology

    Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

    Wilma Tixi, Maricela Maldonado ... Hung Ping Shih
    ECM-Itgb1 signaling and cell-cell adhesion are pivotal and coordinate together to regulate pancreatic islet aggregation, architecture, and functional maturation during development.
    1. Structural Biology and Molecular Biophysics

    Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family

    Stefan Brückner, Rajib Schubert ... Hans-Ulrich Mösch
    Structural, biophysical and physiological analysis reveals how yeast cell surface adhesins evolved to confer self-nonself discrimination in single cells and whole populations.
    1. Cell Biology

    The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell–cell adhesion

    Gareth W Fearnley, Katherine A Young ... Hayley J Sharpe
    Systematic proteomic approaches identify several cell junction regulators as substrates for the homophilic receptor tyrosine phosphatase PTPRK and implicate its pseudophosphatase domain in substrate recognition.
    1. Cell Biology

    The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

    Hugo Siegfried, Georges Farkouh ... Mélina L Heuzé
    Depletion of VAPA in cancer cells induces defects in actin organization, adhesion dynamics and cell migration, together with a perturbation of phosphoinositide levels at the plasma membrane and a lack of anchoring of ER-PM contact sites to focal adhesions.
    1. Neuroscience

    Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans

    Byunghyuk Kim, Scott W Emmons
    The formation of neuronal connectivity of a C. elegans neuron pair is promoted by multiplexed interactions of neural cell adhesion proteins, which are evolutionarily conserved across animal taxa.
    1. Genetics and Genomics
    2. Neuroscience

    Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules

    Savannah G Brovero, Julia C Fortier ... Michelle N Arbeitman
    Analyses of fru P1 neurons that express dpr/DIP genes reveal roles for subsets of neurons in courtship, and the roles of Dpr/DIPs and the sex hierarchy in neuroanatomical sexual dimorphism.
    1. Cell Biology
    2. Immunology and Inflammation

    Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

    Samina Shaheen, Zhengpeng Wan ... Wanli Liu
    The combination of molecular imaging, genetic and pharmacological approaches revealed that BCR signaling and PKCβ-dependent activation of focal adhesion kinase (FAK) is required for B cell mechanosensing.
    1. Cell Biology

    The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells

    Anjali Teckchandani, Jonathan A Cooper
    A ubiquitin E3 ligase localizes to focal adhesions at the front of migrating human cells where it regulates cytoskeletal dynamics by targeting a focal adhesion protein.
    1. Cell Biology

    Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

    David Flores-Benitez, Elisabeth Knust
    The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon, Catherine Theriault ... Arjun Krishnaswamy
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.

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