6,977 results found
    1. Cell Biology

    Reliable cell cycle commitment in budding yeast is ensured by signal integration

    Xili Liu, Xin Wang ... Chao Tang
    The decision to commit to cell division-the Start transition-in budding yeast is governed by time integration of G1 cyclin-CDK activity by the transcription factor Whi5.
    1. Neuroscience

    Cerebellar involvement in an evidence-accumulation decision-making task

    Ben Deverett, Sue Ann Koay ... Samuel S-H Wang
    In a new evidence-accumulation decision-making task, activity of the lateral posterior cerebellum is necessary for accurate performance, and somatic and dendritic activity in Purkinje cells contains choice/evidence and error-related information.
    1. Neuroscience

    Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making

    Claire A Symanski, John H Bladon ... Shantanu P Jadhav
    A novel mechanism of long-range coordination mediated by beta oscillations across sensory and cognitive netowrks for utilization of odor-cued associations and translating them into decisions.
    1. Neuroscience

    Multiple time-scales of decision-making in the hippocampus and prefrontal cortex

    Wenbo Tang, Justin D Shin, Shantanu P Jadhav
    Hippocampal and prefrontal neuronal populations form slow behavioral-timescale (~seconds) and fast cognitive-timescale (~100 ms) sequential activity patterns as theta and replay sequences, which play distinct yet cooperative roles in memory-guided decision-making.
    1. Neuroscience

    Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

    Eric Kenji Lee, Hymavathy Balasubramanian ... Chandramouli Chandrasekaran
    WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

    Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly
    Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
    1. Cell Biology
    2. Immunology and Inflammation

    Transiently heritable fates and quorum sensing drive early IFN-I response dynamics

    Laura C Van Eyndhoven, Vincent PG Verberne ... Jurjen Tel
    Early IFN-I response dynamics are initiated in only fractions of cells, of which their epigenetic profile is transiently heritable and subject to the effects of quorum sensing.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto, Akiko Yamazoe-Umemoto ... Koutarou D Kimura
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Repeated outbreaks drive the evolution of bacteriophage communication

    Hilje M Doekes, Glenn A Mulder, Rutger Hermsen
    Mathematical modelling suggests that the evolution of communication between bacterial viruses requires repeated outbreak events, and the model then predicts typical communication strategies.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz, Laura Mora-Bitria ... Anna-Katerina Hadjantonakis
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.

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