13,015 results found
    1. Computational and Systems Biology

    Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

    Ann Rancourt, Sachiko Sato, Masahiko S Satoh
    Single-cell tracking and cell-fate simulation suggest that low levels of p53 suppress aneuploid cell formation in unstressed cells and also reveal the dual fate of cells lacking p53 in the presence of p53-proficient cells.
    1. Developmental Biology

    scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border

    Alexandre P Thiery, Ailin Leticia Buzzi ... Andrea Streit
    Neural plate border cells co-express neural, neural crest, and placodal transcriptional programs before cell fate decisions occur and are transcriptionally heterogeneous along the antero-posterior and medial-lateral axis.
    1. Developmental Biology
    2. Plant Biology

    Control of plant cell fate transitions by transcriptional and hormonal signals

    Christophe Gaillochet, Thomas Stiehl ... Jan U Lohmann
    HEC transcription factors control the timing of cell fate transitions in a dynamic stem cell system, allowing plants to adapt their developmental program to diverse environments.
    1. Developmental Biology
    2. Genetics and Genomics

    OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification

    Miruna Georgiana Ghinia Tegla, Diego F Buenaventura ... Mark M Emerson
    A retinal gene regulatory network prevents the formation of alternative cell fates from non-stochastic retinal progenitor cells.
    1. Cell Biology
    2. Developmental Biology

    Tgfβ signaling is critical for maintenance of the tendon cell fate

    Guak-Kim Tan, Brian A Pryce ... Ronen Schweitzer
    Conditional deletion of TGFβ signaling results in tenocyte dedifferentiation in vivo demonstrating a key role for TGFβ signaling in the maintenance of the tendon cell fate.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu, Ri-Qi Su ... Xiao Wang
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana, Gabriella Mosca ... Célia Baroux
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz, Laura Mora-Bitria ... Anna-Katerina Hadjantonakis
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Cell Biology
    2. Developmental Biology

    Fat2 polarizes the WAVE complex in trans to align cell protrusions for collective migration

    Audrey Miller Williams, Seth Donoughe ... Sally Horne-Badovinac
    Fat2 signals from the trailing edge of each cell to localize WAVE activity to the leading edge of the cell behind, polarizing protrusive regions within cells and across the epithelium.
    1. Immunology and Inflammation

    Notch and TLR signaling coordinate monocyte cell fate and inflammation

    Jaba Gamrekelashvili, Tamar Kapanadze ... Florian P Limbourg
    Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.

Refine your results by:

Type
Research categories