The human immunodeficiency virus HIV-1 primarily spreads between cells using a method called cell-to-cell infection, suggesting that this process may be a target for anti-viral drugs.
Charlotte E Davies, Jessica E Thomas ... Christopher J Coates
Neither the presence nor the intensity of Hematodinium sp. parasitisation drives co-infection occurrence, severity, or diversity in the ecologically ubiquitous shore crab, Carcinus maenas.
Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.
Naren Srinivasan, Oliver Gordon ... Caetano Reis e Sousa
Extracellular actin is an evolutionarily-conserved signal of tissue injury that is recognised in the fruit fly via similar machinery as reported in vertebrates.
Nicholas van Buuren, Timothy L Tellinghuisen ... Karla Kirkegaard
Interactions between viral genomes within the same cells can impact the selection of drug-resistant variants and this has been finessed by hepatitis C virus.
Temperature and ionic conditions control the mechanical properties of virally encapsidated DNA and act as a switch between synchronized and desynchronized genome ejection dynamics in a phage population.
Marie Alexandre, Romain Marlin ... Rodolphe Thiébaut
A model-based approach for modelling the immune control of viral dynamics is applied to quantify the effect of several SARS-CoV-2 vaccine platforms and to define mechanistic correlates of protection.
Mauricio Seguel, Felipe Montalva ... Nicole Gottdenker
In years with colder ocean temperatures, fur seal pups receive more maternal care and have a better energy balance, clearing hookworm infection earlier, which increases their chances of survival.