707 results found
    1. Cell Biology

    Evolutionary conservation of centriole rotational asymmetry in the human centrosome

    Noémie Gaudin, Paula Martin Gil ... Juliette Azimzadeh
    Centriole rotational asymmetry, a structural property necessary for cytoskeletal organization in unicellular eukaryotes, is broadly conserved in the centrioles of human cells.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

    Christian Arquint, Anna-Maria Gabryjonczyk ... Timm Maier
    Binding of STIL to PLK4's characteristic Polo-box 3 links PLK4 kinase activation to STIL self-association and is a crucial regulatory step for the localized recruitment of downstream factors in centriole duplication.
    1. Developmental Biology

    Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis

    Emma A Hall, Dhivya Kumar ... Pleasantine Mill
    Centriolar satellites facilitate efficient trafficking of proteins to and from centrioles and are required for early steps of cilia formation and timely ciliogenesis in vivo, where mice lacking satellites display perinatal lethality, hydrocephalus, oligospermia, and cerebellar hypoplasia.
    1. Cell Biology

    WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity

    Emmanuelle Steib, Marine H Laporte ... Virginie Hamel
    Centriole integrity is ensured by the connection between the inner scaffold and microtubule triplets through POC16/WDR90 proteins.
    1. Cell Biology

    A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells

    Ewelina Betleja, Rashmi Nanjundappa ... Moe R Mahjoub
    Cells have evolved a mechanism that actively regulates centriole maturation during quiescence.
    1. Cell Biology

    Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles

    Garrett A Greenan, Bettina Keszthelyi ... David A Agard
    Cryo-electron tomography of mammalian and fly centrioles shows that the ninefold symmetry of centrioles is set by species-specific microtubule linkers.
    1. Cell Biology

    Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells

    Jennifer T Wang, Dong Kong ... Tim Stearns
    Deletion of delta-tubulin or epsilon-tubulin in human cells results in loss of centriolar triplet microtubules and defects in centriole structure and inheritance.
    1. Cell Biology

    PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

    Andrew Michael Sydor, Etienne Coyaud ... Vito Mennella
    The previously uncharacterized protein PPP1R35 is a novel centriolar luminal protein critical for centriole elongation by acting in a complex with microcephaly protein RTTN.
    1. Cell Biology
    2. Developmental Biology

    Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

    Andrew Kodani, Timothy W Yu ... Jeremy F Reiter
    To control centriole duplication, centriolar satellite proteins assemble a microcephaly-associated protein complex at the centrosome and activate cyclin-dependent kinase 2.
    1. Cell Biology

    Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

    Kenji Sugioka, Danielle R Hamill ... Bruce Bowerman
    A genetic screen and live cell imaging show that a newly identified coiled-coil protein called SAS-7 is the earliest acting factor in centriole assembly yet identified in the roundworm Caenorhabditis elegans.

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