364 results found
    1. Cell Biology

    Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

    Guadalupe Sepulveda, Mark Antkowiak ... Li-En Jao
    During centrosome maturation, pericentrin is delivered to the centrosome co-translationally by a microtubule- and dynein-dependent process, as pericentrin mRNA is undergoing active translation near the centrosome.
    1. Cell Biology

    Centrosome age regulates kinetochore–microtubule stability and biases chromosome mis-segregation

    Ivana Gasic, Purnima Nerurkar, Patrick Meraldi
    The presence of cenexin at the old centrosome imposes a functional asymmetry on the mitotic spindle that impacts chromosome alignment and segregation.
    1. Cell Biology
    2. Developmental Biology

    Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

    Andrew Kodani, Timothy W Yu ... Jeremy F Reiter
    To control centriole duplication, centriolar satellite proteins assemble a microcephaly-associated protein complex at the centrosome and activate cyclin-dependent kinase 2.
    1. Cell Biology
    2. Developmental Biology

    A molecular mechanism of mitotic centrosome assembly in Drosophila

    Paul T Conduit, Jennifer H Richens ... Jordan W Raff
    The proteins DSpd-2 and Centrosomin assemble into dynamic scaffolds that build from the inside out around the mother centriole and support centrosome maturation.
    1. Cell Biology

    A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome

    Jérémy Magescas, Jenny C Zonka, Jessica L Feldman
    The microtubule organizing potential of the centrosome is inactivated in a stepwise process through phosphatase activity and mechanical disruption to remove an aging matrix of proteins.
    1. Stem Cells and Regenerative Medicine

    Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division

    Cuie Chen, Mayu Inaba ... Yukiko M Yamashita
    Microtubule-depolymerizing kinesin, Klp10A, prevents overgrowth of the mother centrosome to prevent undesirable asymmetries during asymmetric divisions of Drosophila male germline stem cells.
    1. Cell Biology

    Control of endothelial cell polarity and sprouting angiogenesis by non-centrosomal microtubules

    Maud Martin, Alexandra Veloso ... Anna Akhmanova
    Non-centrosomal microtubules are required for endothelial polarization and sprouting, while centrosomally anchored microtubule arrays are both dispensable and insufficient for these processes.
    1. Cell Biology
    2. Developmental Biology

    Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope

    Robert Becker, Silvia Vergarajauregui ... Felix B Engel
    Myogenin promotes centrosome attenuation and establishes the nuclear envelope as the dominant microtubule organization center via the scaffold protein AKAP6, which is required for the recruitment of centrosomal proteins.
    1. Cell Biology

    Evolutionary conservation of centriole rotational asymmetry in the human centrosome

    Noémie Gaudin, Paula Martin Gil ... Juliette Azimzadeh
    Centriole rotational asymmetry, a structural property necessary for cytoskeletal organization in unicellular eukaryotes, is broadly conserved in the centrioles of human cells.
    1. Cell Biology
    2. Immunology and Inflammation

    A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo

    Katrin Möller, Max Brambach ... Francesca Peri
    High-resolution imaging of microglia in zebrafish reveals a rate-limiting role for the centrosome in the engulfment of apoptotic neurons during brain development.

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