1,649 results found
    1. Immunology and Inflammation

    Homeostatic activation of aryl hydrocarbon receptor by dietary ligands dampens cutaneous allergic responses by controlling Langerhans cells migration

    Adeline Cros, Alba De Juan ... Elodie Segura
    Lack of aryl hydrocarbon receptor ligands in the diet of mice increases the inflammatory state in their epidermis, making cutaneous allergic reactions more severe and airway allergy more pronounced after skin sensitization.
    1. Neuroscience

    Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory

    David Levitan, Chenghao Liu ... Sacha B Nelson
    Stk11 and Fos expression plays an important role in CTA long-term memory formation by modulating the intrinsic excitability of BLApn.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

    Thomas Laval, Laura Pedró-Cos ... Caroline Demangel
    Infection with Mycobacterium tuberculosis triggers de novo synthesis of polyunsaturated fatty acids by host macrophages, which promote their antimicrobial responses but feed the intracellular pathogen.
    1. Neuroscience

    Neural correlates of ingroup bias for prosociality in rats

    Inbal Ben-Ami Bartal, Jocelyn M Breton ... Daniela Kaufer
    A distinct neural network, including the nucleus accumbens as a central hub, is active when rats are exposed to trapped ingroup members they had previously helped escape a trap, but not for outgroup members who had not been helped.
    1. Neuroscience

    CA1 pyramidal cell diversity is rooted in the time of neurogenesis

    Davide Cavalieri, Alexandra Angelova ... Rosa Cossart
    Embryonic birthdate is a crucial determinant of heterogeneity among CA1 principal neurons, which include a previously overlooked subpopulation of pioneer neurons.
    1. Neuroscience

    Comparative brain-wide mapping of ketamine- and isoflurane-activated nuclei and functional networks in the mouse brain

    Yue Hu, Wenjie Du ... Yingwei Wang
    Brain-wide activation patterns reveal the distinct and shared neurophysiological impacts of ketamine and isoflurane, highlighting key nuclei involved in the modulation of general anesthesia.
    1. Developmental Biology

    Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

    Fabienne Benz, Viraya Wichitnaowarat ... Stefan Liebner
    Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
    1. Neuroscience

    Network-level changes in the brain underlie fear memory strength

    Josue Haubrich, Karim Nader
    Fear memory intensity modulates brain connectivity patterns, with stronger memories causing a pronounced reduction in interregional coordinated activity and isolation of the amygdala from other key regions.
    1. Neuroscience

    Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential

    Stephanie C Gantz, Maria M Ortiz ... Khaled Moussawi
    Modifying membrane potential by an 'inhibitory' chloride conductance such as PSAM4-GlyR is inherently unstable because the normally low intracellular concentration of chloride is readily increased by influx of chloride.
    1. Neuroscience

    Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

    Travis D Goode, Reed L Ressler ... Stephen Maren
    The bed nucleus of the stria terminalis (BNST) is required for the expression of defensive behavior to uncertain threats, a function that is central to pathological anxiety.

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