1,580 results found
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

    Florian Heigwer, Christian Scheeder ... Michael Boutros
    Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.
    1. Plant Biology

    KATANIN-dependent mechanical properties of the stigmatic cell wall mediate the pollen tube path in Arabidopsis

    Lucie Riglet, Frédérique Rozier ... Thierry Gaude
    KATANIN1 in stigma papilla cells prevents disordered pollen tube growth and straightens pollen tube direction, allowing the pollen tube to find its correct path to the underlying female tissues.
    1. Ecology
    2. Genetics and Genomics

    Decoding the genetic and chemical basis of sexual attractiveness in parasitic wasps

    Weizhao Sun, Michelle Ina Lange ... Jan Buellesbach
    How biologically relevant chemical information can be genetically maintained and conveyed in complex sex pheromonal profiles.
    1. Evolutionary Biology

    Phenotypic plasticity as an adaptation to a functional trade-off

    Xiao Yi, Antony M Dean
    A plastic behavior in Escherichia coli is enabled by a single amino acid replacement in adaption to changing environments.
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    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

    Ryan S Wible, Chidambaram Ramanathan ... Thomas R Sutter
    NRF2 is the mechanism through which oxidative signals directly input into the circadian clockwork to link metabolism and timekeeping in Mus musculus.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides

    Samuel T Coradetti, Dominic Pinel ... Jeffrey M Skerker
    Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.
    1. Developmental Biology

    Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

    Kazuhide S Okuda, Mikaela S Keyser ... Benjamin M Hogan
    Live-imaging of a transgenic reporter of vascular Erk signalling in zebrafish reveals sequential signalling mechanisms during the initiation of regeneration in wounded blood vessels.
    1. Chromosomes and Gene Expression

    DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells

    Faith C Fowler, Bo-Ruei Chen ... Jessica K Tyler
    Molecular analyses and unbiased CRISPR screens reveal that extensive end resection occurs in quiescent cells after inducing DNA double strand breaks, in a manner dependent on DNA-PK.
    1. Ecology
    2. Plant Biology

    Determining the scale at which variation in a single gene changes population yields

    Erica McGale, Henrique Valim ... Ian T Baldwin
    Variation in the gene NaMPK4 in plant populations increases reproductive yield, an effect which appears to be independent of soil water availability, neighbor-scale interactions and associations with arbuscular mycorrhizal fungi.
    1. Ecology
    2. Genetics and Genomics

    Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish

    Elin Sørhus, John P Incardona ... Sissel Jentoft
    Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.

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