Most chloroquine regimens trialled for the treatment of COVID19 will not result in life-threatening cardiovascular toxicity.

Inactivation of KAP1 by mTOR-mediated phosphorylation releases human cytomegalovirus from latency, and has the potential to be used as a therapy to purge the virus from transplant organs.

Pre-clinical and patient data show that inhibition of autophagy with an approved, inexpensive, well-tolerated drug can overcome resistance to BRAF^V600E inhibition in multiple brain tumor subtypes with different resistance mechanisms.

Scratch-AID, a deep learning-based system for automatic quantification of mouse scratching behavior, could replace labor-intensive manual quantification and facilitate high through-put anti-itch drug screening.

We are writing to comment on the article by Watson et al., 2022 about the antimalarial drug tafenoquine.

Circuit and transcriptional analysis shows that genetically defined central amygdala neurons and their projections to the ventral periaqueductal gray mediate behavioral and affective responses to pruritus.

The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.

A novel bioengineered human skeletal muscle model with accurate physiological and pharmacological responses may provide a useful tool for preclinical testing.

A circuit involving Tacr1-expressing neurons in the spinal cord and the parabrachial nucleus controls how mice respond to a wide range of persistently painful stimuli.

A novel mouse model of immunization against Plasmodium chabaudi involving infectious mosquito bites and drug-treatment elicits protection against blood-stage malaria parasites, and shows that protection is not necessarily life cycle stage-specific.