2,754 results found
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    CTCF and cohesin regulate chromatin loop stability with distinct dynamics

    Anders S Hansen, Iryna Pustova ... Xavier Darzacq
    Single-molecule imaging of CTCF and cohesin in live cells suggests that chromatin loops are dynamic structures that frequently form and fall apart.
    1. Physics of Living Systems

    Mesoscale phase separation of chromatin in the nucleus

    Gaurav Bajpai, Daria Amiad Pavlov ... Samuel Safran
    Computer simulations show transitions between novel types of chromatin organization (peripheral, central, conventional) depending on chromatin interactions with itself, the lamin and nuclear hydration, measured in recent experiments.
    1. Chromosomes and Gene Expression

    The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism

    Timothy J Parnell, Alisha Schlichter ... Bradley R Cairns
    A combination of genetics, expression, genomic localization, and genomic nucleosome profiling demonstrates antagonism between two chromatin remodelers that reveal different mechanisms at different promoter architectures.
    1. Chromosomes and Gene Expression

    Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

    Daan Noordermeer, Marion Leleu ... Denis Duboule
    Hox genes are activated sequentially and, at the same time, undergo a transition from an inactive to an active chromatin compartment, most likely to prevent posterior genes being activated too early.
    1. Chromosomes and Gene Expression

    The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1

    Peter J Skene, Aaron E Hernandez ... Steven Henikoff
    The ATP-dependent chromatin remodeler Chd1 controls nucleosome turnover to allow RNA Polymerase to transcribe in vivo.
    1. Developmental Biology
    2. Neuroscience

    Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci

    Sonia Q Sen, Sachin Chanchani ... Chris Q Doe
    Spatial factors generate neuroblast-specific open chromatin, thereby biasing the subsequent binding of transcription factors to produce neuroblast-specific neurons.
    1. Chromosomes and Gene Expression

    Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

    Sarah Lensch, Michael H Herschl ... Lacramioara Bintu
    In a synthetic system, spreading of chromatin-mediated silencing to nearby genes depends on distance and can bypass genetic insulators, while reactivation after release of gene targeting is coordinated by insulators and promoters.
    1. Cell Biology
    2. Evolutionary Biology

    Chromatin is an ancient innovation conserved between Archaea and Eukarya

    Ron Ammar, Dax Torti ... Corey Nislow
    Similarities in the way that nucleosomes are organized into chromatin in archaea and eukaryotes suggest that chromatin might have been involved in gene regulation before its role in DNA packaging evolved.
    1. Chromosomes and Gene Expression

    Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation

    Steven Henikoff, Jorja G Henikoff ... Kami Ahmad
    A simple modification of CUT&Tag chromatin profiling method provides high-quality chromatin accessibility maps and indicates that 'open' chromatin results from a transcription-coupled process at promoters and enhancers.
    1. Chromosomes and Gene Expression

    Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

    Davide M Coda, Tessa Gaarenstroom ... Caroline S Hill
    NODAL/Activin-induced SMAD2 binding directly drives remodeling of both open and closed chromatin and does not directly correlate with temporal patterns of gene expression upon prolonged signaling.

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