A new method for in vivo cell-specific profiling of chromatin accessibility reveals local and global chromatin dynamics during the differentiation of neural and gut stem cell lineages.

OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.

A simple modification of CUT&Tag chromatin profiling method provides high-quality chromatin accessibility maps and indicates that 'open' chromatin results from a transcription-coupled process at promoters and enhancers.

Confronting different models of chromatin accessibility with temporally resolved transcription profiles favors a scenario where transcription factors actively, rather than passively, drive chromatin from the inaccessible to the accessible state.

Profiling chromatin accessibility and nuclear transcription across Caenorhabditis elegans development and ageing generated the first map of transcriptional regulatory elements and their activities across an animal's life.

SCA-seq enables simultaneous detection of spatial interactions, chromatin accessibility, and CpG methylation at single-molecule resolution, advancing multi-omics studies of genome spatial organization.

Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.

Simultaneous multimodal measurement of chromatin accessibility, gene expression, and protein expression provides a unified view of the molecular underpinnings of immune cell state in health and disease.

A new method that measures multiple aspects of chromatin organization in single cells has a possible application to study regulatory processes in heterogeneous samples.

Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.