299 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

    Aaron L Fidler, Carl E Darris ... Billy G Hudson
    Collagen IV is a primordial extracellular matrix component associated with the transition to animal multicellularity, and enabled the formation and evolution of epithelial tissues.
    1. Cell Biology
    2. Immunology and Inflammation

    Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes

    Yiran Zang, Ming Wan ... José Carlos Pastor-Pareja
    Excess membrane can trap outgoing extracellular matrix proteins in secreting cells, leading to pericellular deposits that cause tissue damage.
    1. Cell Biology
    2. Developmental Biology

    Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

    Jennifer Winstanley, Annick Sawala ... Hilary L Ashe
    The in vivo activity of Tolloid during Drosophila dorsal-ventral patterning is regulated by the differential specificity of its non-catalytic domains in mediating substrate and Collagen IV interaction.
    1. Stem Cells and Regenerative Medicine

    Kidney organoids recapitulate human basement membrane assembly in health and disease

    Mychel RPT Morais, Pinyuan Tian ... Rachel Lennon
    Kidney organoids are a high-fidelity system for investigating basement membrane regulation in development and disease.
    1. Cell Biology
    2. Developmental Biology

    Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues

    Kieop Park, Ranjay Jayadev ... David R Sherwood
    Type IV collagen plays a dual role in both structurally fastening tissues and signaling through the discoidin domain receptor 2 to synchronize an integrin adhesion that stabilizes tissue linkage.
    1. Cancer Biology

    Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer

    Zhenzhen Wang, Ziyu Zhai ... Lei Dong
    Inhaled fine particulate matters impair immune defense to accelerate tumorigenesis by pulling the strings of interstitial collagen in lung tissue.
    1. Cell Biology

    Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion

    Caroline Lekszas, Ombretta Foresti ... Thomas Haaf
    The first human TANGO1-associated syndromal disease manifests as impaired collagen secretion, highlighting the importance of TANGO1 in human pathophysiology.
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Nanoscale protein architecture of the kidney glomerular basement membrane

    Hani Suleiman, Lei Zhang ... Adish Dani
    High-resolution optical microscopy is used to reveal the organization of extracellular matrix proteins within the basement membrane of the blood filtration barrier in the kidney at the nanometer scale.
    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles

    Julia Sauerwald, Wilko Backer ... Stefan Luschnig
    Tracheal-derived matrix metalloproteinase 1 activity sustains tracheal branch invasion into myotubes by modulating ECM properties and dynamic behavior of sprouting tip cells.
    1. Cancer Biology
    2. Cell Biology

    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

    Yen-Lin Huang, Ching-Yeu Liang ... Viola Heinzelmann-Schwarz
    Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.

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